Is Oxidative Stress in Mice Brain Regions Diminished by 2-[(2,6-Dichlorobenzylidene)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile?

Table 3

Catalase activity in hippocampus, striatum, frontal cortex, and cerebellum of mice treated with 5TIO1 at doses 0.1, 1, and 10 mg kg⁻¹.

Groups	Catalase (U µg of protein^−1)
	Hippocampus	Striatum	Frontal cortex	Cerebellum
Vehicle	14.22 ± 1.54	19.35 ± 0.46	22.51 ± 0.37	24.61 ± 0.42
5TIO1 0.1	33.62 ± 2.52^a	20.39 ± 2.79	15.41 ± 2.45^a	33.62 ± 2.52^a
5TIO1 1	35.94 ± 2.57^a	26.36 ± 4.93	29.91 ± 5.54^a,b	35.94 ± 2.57^a
5TIO1 10	34.98 ± 3.24^a	30.52 ± 7.12^a,b	34.03 ± 3.32^a,b,c	34.98 ± 3.24^a

Male mice (25–30 g, 2 month-old) were intraperitoneally treated with doses of 5TIO1 (0.1, 1, and 10 mg kg⁻¹, 𝑛=7, 5TIO1 groups) and the control animals with 0.05% Tween 80 dissolved in 0.9% saline (𝑛=7, Vehicle). Results are expressed as means ± SD for the number of animals shown inside in parenthesis. Differences in experimental groups were determined by two-tailed Analysis of Variance (ANOVA). ^a𝑃<0.05 compared to the control group (ANOVA and 𝑡-Student-Neuman-Keuls as post hoc test); ^b𝑃<0.05 compared to the 5TIO1 0.1 group (ANOVA and 𝑡-Student-Neuman-Keuls as post hoc test); ^c𝑃<0.05 compared to the 5TIO1 1 group (ANOVA and 𝑡-Student-Neuman-Keuls as post hoc test).