Exacerbated Airway Toxicity of Environmental Oxidant Ozone in Mice Deficient in Nrf2
Figure 4
Lung redox status. (a) Malondialdehyde (MDA) levels conjugated with the substrate TBARS in lung homogenates from and mice after 6 hr or 24, 48, and 72 hr exposure to 0.3 ppm (left) and 3, 6, and 24 hr after 3 hr exposure to 2 ppm (right). /group. (b) Oxidized protein levels in lung homogenates from and mice after exposure to air, 0.3 ppm (left), or 2 ppm (right). /group. (c) Total glutathione (GSH) in bronchoalveolar lavage returns (100 μL) from and mice after exposure to air, 0.3 ppm (left), or 2 ppm (right). /group. All data are presented as mean ± SEM. *Significantly different from genotype-matched air control mice (). +Significantly lower than exposure-matched mice ().
