Sivelestat preserves LV and coronary vascular function in ischemia-reperfusion. (a) Effect of sivelestat on LV function and infarct size. Sivelestat significantly improved recovery of developed pressure, , and rate pressure product (RPP) as compared to hearts that did not receive low flow (25 min isc) ( per group). (b) Rebound in coronary flow. Sivelestat significantly preserved vasoreactivity at the end of reperfusion as shown through the rebound in coronary flow after one minute of acetylcholine (1 μM) infusion (/group).
