| | Domain | Amino acid residues | DNA mutation | Cancer types (cases) | References | | Locus | Wild type | Mutant |
| | DLG motif | 24 | W (Trp) | C (Cys) | c.72G>C/G>T | NSCLC, neck, ESC | [54, 62] | | K (Lys) | c.72T>C | ESC | [62] | | 26 | Q (Gln) | E (Glu) | c.76C>G | NSCLC, ESC | [54, 62] | | 27 | D (Asp) | G (Gly)* | c.80G>A | NSCLC | [60] | | Y (Tyr) | c.79G>T | ESC | [61] | | 28 | I (Ile) | T (Thr) | c.83C>T | NSCLC | [54] | | 29 | D (Asp) | G (Gly) | c.86A>G | Head and neck, ESC | [54, 62] | | H (His) | c.85G>C | NSCLC, laynx | [60, 61] | | 30 | L (Leu) | F (Phe) | c.88C>T | NSCLC, ESC | [54, 62] | | 31 | G (Gly) | A (Ala) | c.92G>C | NSCLC, ESC, skin | [54, 60–62] | | 32 | V (Val) | T (Thr) | c.95T>G | NSCLC | [54] | | del | c.93_95delAGT | ESC | [61] | | 33–36 | S-R-E-V | S-R-E-V-S-R-E-V* | c.97_108dupAGTCGAGCCGTA | ESC | [61] | | 34 | R (Arg) | Q (Gln) | c.101G>A | NCSCL | [54, 60, 61] | | P (Pro) | c.101G>C | NSCLC | [63] |
| ETGF motif
| 75 | Q (Gln) | H (His) | c.225A>C | Head and neck, ESC | [54, 62] | | 77 | D (Asp) | V (Val) | c.230A>T | NSCLC, ESC | [54, 60, 62] | | G (Gly) | c.230A>G | ESC | [62] | | A (Ala) | c.230A>C | NSCLC | [61] | | N (Asn) | c.229G>A | Larynx | [61] | | 78 | E (Glu) | K (Lys) | c.232G>A | NSCLC, ESC | [54, 62] | | 79 | E (Glu) | K (Lys) | c.235G>A | NSCLC, ESC | [54, 61, 62] | | Q (Gln) | c.235G>C | NSCLC, ESC | [54, 60–62] | | G (Gly) | c.236A>G | Larynx | [61] | | E-E | c.234_236dupAGA | ESC | [61] | | 80 | T (Thr) | K (Lys) | c.239C>A/C>G | NSCLC, ESC | [54, 61, 62] | 80
| T (Thr)
| P (Phe) | c.238A>C | ESC | [62] | | I (Ile) | c.239C>T | Head and neck | [54] | | A (Ala) | c.238A>G | NSCLC | [63] | | 81 | G (Gly) | V (Val) | c.242G>T | ESC | [61] | | D (Asp) | c.242G>A | NSCLC, ESC | [60–62] | | 82 | E (Glu) | D (Asp) | c.246A>T | ESC, oral cancer cell line | [54, 62] | | G (Gly) | c.245A>G | NSCLC | [54] | | Q (Gln)* | c.244G>C | NSCLC, ESC | [60, 61] | | V (Val)* | c.245A>T | ESC | [61] | | 83 | F (Phe) | L (Leu)* | c.247T>C | NSCLC | [60] |
|
|
