Comparative Effects of Biodynes, Tocotrienol-Rich Fraction, and Tocopherol in Enhancing Collagen Synthesis and Inhibiting Collagen Degradation in Stress-Induced Premature Senescence Model of Human Diploid Fibroblasts

Figure 6

Effects of biodynes, TRF and tocopherol on MMP9 gene expression and MMP-9 activity in HDFs. MMP9 expression (a). Biodynes, TRF, tocopherol and BTT significantly down regulated MMP9 expression compared to SIPS. MMP-9 activity (b). Biodynes, tocopherol and BTT significantly decreased MMP-9 activity. ^aDenotes 𝑃<0.05 compared to SIPS, ^adenotes 𝑃<0.05 compared to biodynes, ^cdenotes 𝑃<0.05 compared to TRF, ^ddenotes 𝑃<0.05 compared to tocopherol. Data are presented as the mean of three experiments ±S.D, 𝑛=6.

(a)

(b)