NRF2 Protection against Liver Injury Produced by Various Hepatotoxicants

Table 3

Inflammatory gene expressions under the challenge of hepatotoxicants.

	Nrf2-null	Wild-type	Keap1-Kd	Keap1-HKO
MIP-2	+++	++	+	±
mKC	+++	++	+	±
ICAM1	++	++	+	+
IL-1β	+++	++	+	±
IL-6	++	+	±	±
TNFα	++	+	±	±
Egr1	++	++	+	+
Ho-1	+++	++	+	+

MIP-2: macrophage inflammatory protein 2; mKC: mouse keratinocyte-derived chemokine; IL-1β: interleukin-1β; IL-6: interleukin-6; TNFα: tumor necrosis factor α. Ho-1: heme oxygenase-1. “+++” indicates significant increase; “++” indicates moderate increase; “+” indicates slight mild increase; “±” indicates slight increase. These inflammatory gene expression profiles are similar for the hepatotoxicity produced by acetaminophen, carbon tetrachloride, microcystin, phalloidin, and furosemide.