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Oxidative Medicine and Cellular Longevity
Volume 2013, Article ID 340731, 17 pages
Research Article

Hepatic Gene Expression Profiling in Nrf2 Knockout Mice after Long-Term High-Fat Diet-Induced Obesity

1Division of Endocrinology, Department of Internal Medicine, Medical School, University of Patras, 26504 Patras, Greece
2Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
3Laboratory of Virology, Medical School, University of Crete, 71110 Heraklion, Greece
4Department of Biological Sciences, Molecular Medicine Research Center and Laboratory of Molecular and Medical Genetics, University of Cyprus, 1678 Nicosia, Cyprus

Received 9 January 2013; Revised 5 March 2013; Accepted 9 March 2013

Academic Editor: Jingbo Pi

Copyright © 2013 Dionysios V. Chartoumpekis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The supplementary material comprises of two figures and three tables. A heatmap of the differentially expressed genes between WT and Nrf2-KO mice after HFD feeding is depicted in figure S1. Figure S2 shows a gene network of some of the differentially expressed genes that also comprises Nrf2. The primer sequences used in this study are provided in Table S1. The 428 genes that were over-expressed as well the 173 genes that were under-expressed in the liver of the Nrf2-KO mice compared to their WT counterparts after 180 days on HFD, are presented in Tables S2 and S3 correspondingly.

  1. Supplementary Materials