TY - JOUR
A2 - Parinandi, Narasimham L.
AU - Guzmán-Beltrán, Silvia
AU - Pedraza-Chaverri, José
AU - Gonzalez-Reyes, Susana
AU - Hernández-Sánchez, Fernando
AU - Juarez-Figueroa, Ulises E.
AU - Gonzalez, Yolanda
AU - Bobadilla, Karen
AU - Torres, Martha
PY - 2013
DA - 2013/02/24
TI - Nordihydroguaiaretic Acid Attenuates the Oxidative Stress-Induced Decrease of CD33 Expression in Human Monocytes
SP - 375893
VL - 2013
AB - Nordihydroguaiaretic acid (NDGA) is a natural lignan with recognized antioxidant and beneficial properties that is isolated from Larrea tridentata. In this study, we evaluated the effect of NDGA on the downregulation of oxidant stress-induced CD33 in human monocytes (MNs). Oxidative stress was induced by iodoacetate (IAA) or hydrogen peroxide (H2O2) and was evaluated using reactive oxygen species (ROS) production, and cell viability. NDGA attenuates toxicity, ROS production and the oxidative stress-induced decrease of CD33 expression secondary to IAA or H2O2 in human MNs. It was also shown that NDGA (20 μM) attenuates cell death in the THP-1 cell line that is caused by treatment with either IAA or H2O2. These results suggest that NDGA has a protective effect on CD33 expression, which is associated with its antioxidant activity in human MNs.
SN - 1942-0900
UR - https://doi.org/10.1155/2013/375893
DO - 10.1155/2013/375893
JF - Oxidative Medicine and Cellular Longevity
PB - Hindawi Publishing Corporation
KW -
ER -