Nordihydroguaiaretic Acid Attenuates the Oxidative Stress-Induced Decrease of CD33 Expression in Human Monocytes

Figure 1

Effect of (a) NDGA, (b) IAA, and (c) H₂O₂ on the viability of human MN and THP-1 cells. (a) NDGA (0–30 μM) was added for 120 h before the measurement of viability. In addition, cells were exposed to (b) IAA (0–100 μM) or (c) H₂O₂ (0–20 mM) for 2 h. At the end of the exposition time, the media containing IAA and H₂O₂ were replaced with fresh medium. Viability was assessed at the end of 24 h of incubation. The number of viable cells is expressed as index of MTT reduction. Data are expressed as mean ± SEM; 𝑛=5. ^∗𝑃<0.05 versus MN (without treatment) and ⁺𝑃<0.05 versus THP-1 (without treatment). MN: human monocytes; THP1: human acute monocytic leukemia cell line.

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