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Oxidative Medicine and Cellular Longevity
Volume 2013 (2013), Article ID 408260, 5 pages
http://dx.doi.org/10.1155/2013/408260
Research Article

Antioxidants Supplementation in Elderly Cardiovascular Patients

Instituto de Investigaciones Cardiológicas (ININCA), Universidad de Buenos Aires (UBA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), M.T. de Alvear 2270 (C1122AAJ), Buenos Aires, Argentina

Received 26 August 2013; Revised 5 November 2013; Accepted 8 November 2013

Academic Editor: Sathyasaikumar V. Korrapati

Copyright © 2013 Matilde Otero-Losada et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Supplementation with antioxidants and its benefit-risk relationship have been largely discussed in the elderly population. We evaluated whether antioxidants supplementation improved the biochemical profile associated with oxidative metabolism in elderly cardiovascular patients. Patients ( ) received daily supplementation with α-TP 400 mg, beta-carotene 40 mg, and vitamin C 1000 mg for 2 months (treatment). Plasma concentrations of alpha-tocopherol (α-TP), β-carotene (βC), ubiquinol-10 (QH-10), glutathione, and thiobarbituric acid reactive substances (TBARS) were determined before and after treatment. Response to treatment was dependent on pretreatment α-TP and βC levels. Increase in α-TP and βC levels was observed only in patients with basal levels <18 μM for α-TP ( ) and <0.30 μM for βC ( ). Ubiquinol-10, glutathione, and TBARS were unaffected by treatment: QH-10 (+57%, , , and N.S.), glutathione (+21%, , , and N.S.), and TBARS (−29%, , , and N.S.). Treatment reduced oxidative metabolism: 5.3% versus 14.6% basal value ( , ). Basal TBARS/α-TP ratio was higher in smokers compared to nonsmokers: 0.11 ± 0.02 versus 0.06 ± 0.01 ( , ). Response to antioxidant supplementation was dependent on basal plasma levels of α-TP and βC. Smoking status was strongly associated with atherosclerotic cardiovascular disease and high TBARS/α-TP ratio (lipid peroxidation).