Sulforaphane Enhances the Ability of Human Retinal Pigment Epithelial Cell against Oxidative Stress, and Its Effect on Gene Expression Profile Evaluated by Microarray Analysis

Table 2

Hypervariable genes responsive to SF treatment in cultured human RPE cells*.

Accession no.	Gene symbol	Description	Cluster order	Cluster
AI034387	TBC1D8	TBC1 domain family, member 8 (with GRAM domain)	1	1
AU152969	TKT	Transketolase (Wernicke-Korsakoff syndrome)	2	1
AI298887	CSNK2A1	Casein kinase 2, alpha 1 polypeptide	3	1
BF515595	PIP5K1A	Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha	4	1
BE620457	NRP1	Neuropilin 1	5	1
AW026379	TNFRSF11A	Tumor necrosis factor receptor superfamily,	6	1
		Member 11a, NFKB activator
AW071793	MXD1	MAX dimerization protein 1	7	1
AY137580	CDC25A	Cell division cycle 25A	8	1
M15565	TRA	T cell receptor alpha locus	9	2
BC017854	EMP1	Epithelial membrane protein 1	10	2
AW772192	ERBB4	V-erb-a erythroblastic leukemia viral	11	2
		Oncogene homolog 4 (avian)
AW264269	UACA	Uveal autoantigen with coiled-coil	12	2
		Domains and ankyrin repeats
NM_021146	ANGPTL7	Angiopoietin-like 7	13	2
NM_006472	TXNIP	Thioredoxin interacting protein	14	2
BC032027	SLIT3	Slit homolog 3 (Drosophila)	15	2
AF455755	BCL2L11	BCL2-like 11 (apoptosis facilitator)	16	2
AF161419	ING3	Inhibitor of growth family, member 3	17	2
M13436	INHBA	Inhibin, beta A (activin A, activin AB alpha polypeptide)	18	2
NM_005360	MAF	V-maf musculoaponeurotic fibrosarcoma	19	2
		Oncogene homolog (avian)
NM_003014	SFRP4	Secreted frizzled-related protein 4	20	2
X57348	SFN	Stratifin	21	2
AJ224869	CXCR4	Chemokine (C-X-C motif) receptor 4	22	3
NM_003877	SOCS2	Suppressor of cytokine signaling 2	23	3
NM_000585	IL15	Interleukin 15	24	3
NM_014862	ARNT2	Aryl-hydrocarbon receptor nuclear translocator 2	25	3
NM_000710	BDKRB1	Bradykinin receptor B1	26	3
NM_014391	ANKRD1	Ankyrin repeat domain 1 (cardiac muscle)	27	3
NM_001561	TNFRSF9	Tumor necrosis factor receptor superfamily, member 9	28	3
NM_000359	TGM1	Transglutaminase 1 (K polypeptide epidermal type I,	29	4
		Protein-glutamine-gamma-glutamyl transferase)
BE973687	HES1	Hairy and enhancer of split 1, (Drosophila)	30	4
NM_018444	PPM2C	Protein phosphatase 2C, magnesium-dependent,	31	4
		Catalytic subunit
AI263909	RHOB	Ras homolog gene family, member B	32	4
N21202	DAB2	Disabled homolog 2, mitogen-responsive	33	4
		Phosphoprotein (Drosophila)
BF432648	TNFRSF19	Tumor necrosis factor receptor superfamily, member 19	34	4
AW779556	STK38L	Serine/threonine kinase 38 like	35	4
N55072	PRDX6	Peroxiredoxin 6	36	5
NM_013370	OKL38	Pregnancy-induced growth inhibitor	37	5
AV705233	MGST1	Microsomal glutathione S-transferase 1	38	5
NM_002166	ID2	Inhibitor of DNA binding 2, dominant negative	39	6
		Helix-loop-helix protein
AB044088	BHLHB3	Basic helix-loop-helix domain containing, class B, 3	40	6
AA173223	FLJ37927	CDC20-like protein	41	6
AI888037	GSR	Glutathione reductase	42	6
AB018580	AKR1C3	Aldo-keto reductase family 1, member C3	43	6
		(3-alpha hydroxysteroid dehydrogenase, type II)
BC002670	SERTAD1	SERTA domain containing 1	44	7
AK021780	PTDSR	Phosphatidylserine receptor	45	7
BC000737	RGS4	Regulator of G-protein signalling 4	46	7
X59065	FGF1	Fibroblast growth factor 1 (acidic)	47	7
NM_002053	GBP1	Guanylate binding protein 1,	48	7
		Interferon-inducible, 67 kDa
NM_002575	SERPINB2	Serpin peptidase inhibitor, clade B	49	7
		(ovalbumin), member 2
BG250721	KLF6	Kruppel-like factor 6	50	7
NM_005346	HSPA1B	Heat shock 70 kDa protein 1B	51	7
NM_002133	HMOX1	Heme oxygenase (decycling) 1	52	7
AI459194	EGR1	Early growth response 1	53	7
NM_000402	G6PD	Glucose-6-phosphate dehydrogenase	54	8
NM_001498	GCLC	Glutamate-cysteine ligase, catalytic subunit	55	8
NM_001394	DUSP4	Dual specificity phosphatase 4	56	8
NM_006328	RBM14	RNA binding motif protein 14	57	8
AW300045	HIPK2	Homeodomain interacting protein kinase 2	58	8

∗Genes are in the same order as presented in Figure 2.