Resveratrol Protects the Brain of Obese Mice from Oxidative Damage

Table 3

Effect of resveratrol on the levels of nonenzymic antioxidants in lean and obese mice brains.

Parameter	Lean	Lean + Res	ob/ob	ob/ob + Res
Ascorbic acid	1.57 ± 0.20	1.51 ± 0.21	0.76±0.12^a∗∗∗	1.32±0.18^b∗∗∗
𝛼-Tocopherol	1.62 ± 0.19	1.58 ± 0.19	1.06±0.20^a∗∗∗	1.42±0.19^b∗
GSH	4.73 ± 0.60	5.01 ± 0.43	3.77±0.31^a∗∗	4.44±0.37^b∗∗
GSSG	1.71 ± 0.20	1.88 ± 0.24	1.65±0.20^aNS	1.73±0.19^bNS
GSH/GSSG	2.69 ± 0.16	2.74 ± 0.19	2.30±0.12^a∗∗∗	2.57±0.11^b∗∗
Redox index	0.023 ± 0.001	0.024 ± 0.001	0.021±0.001^a∗∗∗	0.023±0.001^b∗∗

Values are expresses as mean ± S.D. for six mice in each group. Ascorbic acid, mg/mg protein; 𝛼-tocopherol: mg/mg protein; GSH and GSSG: nmol/mg protein. Values are statistically significant at ^∗∗∗𝑃<0.001, ^∗∗𝑃<0.01, and ^∗𝑃<0.05. ^aob/ob mice were compared with lean control mice; ^bob/ob mice were compared with ob/ob-resveratrol treated mice. NS represents nonsignificant.