|
| Gene | Description | Fold change by KEAP1 knockdown
(KEAP1 knockdown/sc control) |
|
| Direct antioxidant proteins |
|
| SOD1 | Superoxide dismutase 1 | — |
| SOD2 | Superoxide dismutase 2 | — |
| GPX1 | Glutathione peroxidase 1 | — |
| GPX2 | Glutathione peroxidase 2 | 1.88 |
| PRDX6 | Peroxiredoxin 6 | — |
| MT1A | Metallothionein 1A | 1.78 |
| MT2A | Metallothionein 2A | — |
|
| Thiol biosynthesis and recycling enzymes |
|
| GCLC | Glutamate-cysteine ligase, catalytic subunit | 2.50 |
| GCLM | Glutamate-cysteine ligase, modifier subunit | 2.34 |
| GSR | Glutathione reductase | 1.66 |
| TXN | Thioredoxin | 1.83 |
| TXNRD | Thioredoxin reductase | 2.23 |
|
| Conjugation enzymes |
|
| GSTA2 | Glutathione S-transferase A2 | 1.64 |
| GSTA3 | Glutathione S-transferase A3 | 2.48 |
| GSTM1 | Glutathione S-transferase Mu 1 | 1.57 |
| GSTM2 | Glutathione S-transferase Mu 2 | 2.51 |
| MGST2 | Microsomal glutathione S-transferase 1 | — |
| UGT1A1 | UDP glucuronosyltransferase 1A1 | — |
| UGT1A6 | UDP glucuronosyltransferase 1A6 | 2.60 |
| SULT2A1 | Sulfotransferase family 2A1 | — |
|
| Reductase and hydrolase |
|
| NQO1 | NAD(P)H:quinone oxidoreductase 1 | 2.26 |
| EPHX1 | Epoxide hydrolase 1 | 2.50 |
| ALDH | Aldehyde dehydrogenase | — |
| AKR1C1/2 | Aldo-keto reductase family 1C1/2 | 24.08 |
| AKR1C2 | Aldo-keto reductase family 1C2 | 34.64 |
| AKR1C3 | Aldo-keto reductase family 1C3 | 6.44 |
| AKR1B1 | Aldo-keto reductase family 1B1 | 2.02 |
| AKR1B10 | Aldo-keto reductase family 1B10 | 6.56 |
|
| Stress response proteins |
|
| HMOX1 | Heme oxygenase 1 | 1.62 |
| FTH1 | Ferritin, heavy polypeptide 1 | — |
|
| Drug transporters |
|
| MRP2 | Multidrug resistance associated protein 2 | 10.23 |
| MRP3 | Multidrug resistance associated protein 3 | 1.82 |
|
