Effects of Open versus Laparoscopic Nephrectomy Techniques on Oxidative Stress Markers in Patients with Renal Cell Carcinoma
Table 1
Lipid peroxidation products level and antioxidant enzymes activity in patients with renal cell carcinoma before and after radical nephrectomy by open surgery and laparoscopy.
Open radical nephrectomy (n = 21)
Before surgery
12 hours after surgery
5 days after surgery
TBARSplasma nmol MDA/mL
0.51 ± 0.14
0.53 ± 0.12
0.55 ± 0.14
TBARSerythrocytes nmol MDA/gHb
37.6 ± 13.2
39.0 ± 18.2
38.6 ± 14.5
CAT 104 IU/gHb
61.4 ± 18.6
67.2 ± 27.0
61.4 ± 19.6
SOD U/gHb
1167.6 ± 345.4
1132.5 ± 193.3
1110.3 ± 222.9
GPx U/gHb
9.0 ± 3.7
8.8 ± 3.2
7.8 ± 3.5
Laparoscopic radical nephrectomy (n = 23)
Before laparoscopy
12 hours after laparoscopy
5 days after laparoscopy
TBARSplasma nmol MDA/mL
0.45 ± 0.11
0.56 ± 0.13
0.56 ± 0.18
TBARSerythrocytes nmol MDA/gHb
32.6 ± 19.2
40.1 ± 12.6
35.4 ± 12.9
CAT 104 IU/gHb
74.7 ± 32.3
55.8 ± 15.9
61.3 ± 17.3
SOD U/gHb
1161.0 ± 298.2
1060.3 ± 135.1
1011.7 ± 131.3
GPx U/gHb
6.9 ± 3.9
9.9 ± 3.1
6.5 ± 2.9
No statistically significant differences between open surgery and laparoscopy. TBARS: thiobarbituric acid reactive substances; CAT: catalase; SOD: superoxide dismutase; GPx: glutathione peroxidase.
