Effects of Open versus Laparoscopic Nephrectomy Techniques on Oxidative Stress Markers in Patients with Renal Cell Carcinoma

Table 2

Lysosomal enzymes and protease inhibitor activity in patients with renal cell carcinoma before and after radical nephrectomy by open surgery and laparoscopy.

	Open radical nephrectomy (𝑛=21)
	Before surgery	12 hours after surgery	5 days after surgery
AcP (10^−2 nM p-nitrophenol/mg protein/min)	1.87 ± 0.78	2.46 ± 0.89	2.22 ± 0.99
ASA (10^−3 nM NCS/mg protein/min)	2.13 ± 0.46	1.58 ± 0.59^a	1.66 ± 0.68^a
CTSD (10^−2 nM tyrosine/mg protein/min)	2.31 ± 1.19	4.10 ± 1.82^a	4.37 ± 2.17^aa
AAT (mg trypsin/mL serum)	0.62 ± 0.2	0.43 ± 0.2	0.79 ± 0.2^bbb
	Laparoscopic radical nephrectomy (𝑛=23)
	Before laparoscopy	12 hours after laparoscopy	5 days after laparoscopy
AcP (10^−2 nM p-nitrophenol/mg protein/min)	2.07 ± 0.86	1.62 ± 0.79	1.61 ± 0.58
ASA (10^−3 nM NCS/mg protein/min)	2.22 ± 0.36	1.40 ± 0.72^ccc	1.23 ± 0.51^ccc
CTSD (10^−2 nM tyrosine/mg protein/min)	2.81 ± 0.97	4.53 ± 2.01^cc	4.35 ± 2.10^c
AAT (mg trypsin/mL serum)	0.61 ± 0.2	0.49 ± 0.2	0.74 ± 0.3^d

No statistically significant differences between open surgery and laparoscopy.
Statistically significant differences: versus before open surgery: ^a𝑃<0.05, ^aa𝑃<0.01; versus 12 hours after open surgery: ^bbb𝑃<0.001; versus before laparoscopy: ^c𝑃<0.05 and ^cc𝑃<0.01 and ^ccc𝑃<0.001; versus 12 hours after laparoscopy: ^d𝑃<0.05.
AcP: acid phosphatase; AAT: α ₁-antitrypsin; ASA: arylsulphatase; CTSD: cathepsin D.