Oxidative Medicine and Cellular Longevity / 2013 / Article / Tab 2

Research Article

Gamma-Tocotrienol Modulated Gene Expression in Senescent Human Diploid Fibroblasts as Revealed by Microarray Analysis

Table 2

Differentially expressed genes list in γ-tocotrienol-treated senescent HDFs.

Gene Ontology/accession numberGene symbolFold changeRegulation

Protein transport
 NM_020751.1COG62.9372108Upregulated
 NM_022374.1ARL6IP22.4375103Upregulated
 NM_017954.8CADPS22.4749646Upregulated
 NM_004794.2RAB33A4.2599683Upregulated
 NM_001660.2ARF43.6646543Upregulated
 NM_021930.3RINT-11.6876434Upregulated
 NM_001031677.2RAB242.3763354Upregulated
 NM_013248.2NXT13.5031867Upregulated
 NM_014177.1C18orf551.5897815Upregulated
 NM_017986.2GPR172B2.2754004Upregulated
Ion transport
 NM_000725.2CACNB32.0575228Downregulated
 NM_002245.2KCNK14.019881Upregulated
 NM_022055.1KCNK122.6714919Upregulated
 NM_012463.2ATP6V0A22.7435005Upregulated
 NM_005175.2ATP5G12.527163Upregulated
 NM_000785.3CYP27B17.801915Upregulated
Negative regulation of interleukin-6 production
 NM_203472.1SELS2.317949Upregulated
 NM_007199.1IRAK32.630288Upregulated
Immune response
 NM_002162.2ICAM33.910169Upregulated
Cytokine mediated signal transduction
 NM_203453.2PPAPDC21.8218696Downregulated
Apoptosis
 NM_018530.1GSDML2.4119947Upregulated
 NM_018130.2SHQ11.8244729Upregulated
 NM_018456.4EAF27.062471Upregulated
 NM_018145.1FAM82C1.6341798Upregulated
 NM_024310.2PLEKHF12.9315765Upregulated
 NM_001012398.1AKTIP2.6247795Upregulated
Response to stress
 NM_005347.2HSPA55.951358Upregulated
 NM_021237.3SELK3.3043954Upregulated
 NM_014445.2SERP13.263752Upregulated
Cell redox homeostasis
 NM_016417.2GLRX51.7182248Upregulated
Cell cycle
 NM_006545.4TUSC45.8936715Upregulated
 NM_016948.1PARD6A2.2347567Upregulated
Regulation of transcription
 NM_005444.1RQCD12.0665886Upregulated
 NM_004634.2BRPF11.8511329Upregulated
 NM_003408.1ZFP372.5321555Upregulated
 NM_015394.4ZNF102.5174437Upregulated
 NM_001080485.1ZNF2751.8915362Upregulated
 NM_005088.2CXYorf32.2247052Upregulated
 NM_032758.3PHF5A2.0002973Upregulated
 NM_022366.1TFB2M2.2978535Upregulated
 NM_145805.1ISL22.0560906Upregulated
Protein binding
 NM_021934.3C12orf442.943061Upregulated
 NM_181291.1WDR201.9003692Upregulated
 NM_006207.1PDGFRL3.129943Upregulated
Protein folding
 NM_021800.2DNAJC124.182389Upregulated
Endoplasmic reticulum unfolded protein response
 NM_001010990.1HERPUD16.5408597Upregulated
Regulation of RhoGTPase activity
 NM_153213.2ARHGEF192.899712Upregulated
Regulation of rab GTPase activity
 NM_022771.3TBC1D152.361947Upregulated
 NM_020705.1TBC1D243.0267975Upregulated
Cell-cell signalling
 NM_001005914.1SEMA3B1.764685Upregulated
 NM_032331.2MGC24082.6944642Upregulated
 NM_001407.1CELSR33.9751458Upregulated
Translation
 NM_181463.1MRPL553.1179419Upregulated
 NM_003136.2SRP542.6215558Upregulated
Electron transport chain
 NM_025147.2COQ10B1.7724766Upregulated
 NM_007022.3CYB561D23.542795Upregulated
Signal transduction
 NM_133173.2APBB32.0743015Upregulated
 NM_016115.3ASB32.5060174Upregulated
Cell proliferation
 NM_206825.1GNL34.2791877Upregulated
DNA replication
 NM_017443.3POLE33.112311Upregulated
Oxidoreductase
 NM_017758.2ALKBH53.526197Upregulated
Microtubule sitoplamic organization
 NM_014171.3CRIPT2.496879Upregulated
Growth
 NM_031479.3INHBE24.436758Upregulated
Biosynthesis process
 NM_014305.1TGDS2.4665043Upregulated
 NM_133443.1GPT26.0515475Upregulated
 NM_005768.5OACT52.454743Downregulated
Modification-dependent protein catabolic process
 NM_203301.1FBXO331.5563589Upregulated
 NM_015984.1UCHL52.2333875Upregulated
Hydrolase activity
 NM_203453.2PPAPDC21.8218696Downregulated
Proteolysis
 NM_032549.1IMMP2L1.596754Downregulated