Gamma-Tocotrienol Modulated Gene Expression in Senescent Human Diploid Fibroblasts as Revealed by Microarray Analysis

Table 2

Differentially expressed genes list in γ-tocotrienol-treated senescent HDFs.

Gene Ontology/accession number	Gene symbol	Fold change	Regulation
Protein transport
NM_020751.1	COG6	2.9372108	Upregulated
NM_022374.1	ARL6IP2	2.4375103	Upregulated
NM_017954.8	CADPS2	2.4749646	Upregulated
NM_004794.2	RAB33A	4.2599683	Upregulated
NM_001660.2	ARF4	3.6646543	Upregulated
NM_021930.3	RINT-1	1.6876434	Upregulated
NM_001031677.2	RAB24	2.3763354	Upregulated
NM_013248.2	NXT1	3.5031867	Upregulated
NM_014177.1	C18orf55	1.5897815	Upregulated
NM_017986.2	GPR172B	2.2754004	Upregulated
Ion transport
NM_000725.2	CACNB3	2.0575228	Downregulated
NM_002245.2	KCNK1	4.019881	Upregulated
NM_022055.1	KCNK12	2.6714919	Upregulated
NM_012463.2	ATP6V0A2	2.7435005	Upregulated
NM_005175.2	ATP5G1	2.527163	Upregulated
NM_000785.3	CYP27B1	7.801915	Upregulated
Negative regulation of interleukin-6 production
NM_203472.1	SELS	2.317949	Upregulated
NM_007199.1	IRAK3	2.630288	Upregulated
Immune response
NM_002162.2	ICAM3	3.910169	Upregulated
Cytokine mediated signal transduction
NM_203453.2	PPAPDC2	1.8218696	Downregulated
Apoptosis
NM_018530.1	GSDML	2.4119947	Upregulated
NM_018130.2	SHQ1	1.8244729	Upregulated
NM_018456.4	EAF2	7.062471	Upregulated
NM_018145.1	FAM82C	1.6341798	Upregulated
NM_024310.2	PLEKHF1	2.9315765	Upregulated
NM_001012398.1	AKTIP	2.6247795	Upregulated
Response to stress
NM_005347.2	HSPA5	5.951358	Upregulated
NM_021237.3	SELK	3.3043954	Upregulated
NM_014445.2	SERP1	3.263752	Upregulated
Cell redox homeostasis
NM_016417.2	GLRX5	1.7182248	Upregulated
Cell cycle
NM_006545.4	TUSC4	5.8936715	Upregulated
NM_016948.1	PARD6A	2.2347567	Upregulated
Regulation of transcription
NM_005444.1	RQCD1	2.0665886	Upregulated
NM_004634.2	BRPF1	1.8511329	Upregulated
NM_003408.1	ZFP37	2.5321555	Upregulated
NM_015394.4	ZNF10	2.5174437	Upregulated
NM_001080485.1	ZNF275	1.8915362	Upregulated
NM_005088.2	CXYorf3	2.2247052	Upregulated
NM_032758.3	PHF5A	2.0002973	Upregulated
NM_022366.1	TFB2M	2.2978535	Upregulated
NM_145805.1	ISL2	2.0560906	Upregulated
Protein binding
NM_021934.3	C12orf44	2.943061	Upregulated
NM_181291.1	WDR20	1.9003692	Upregulated
NM_006207.1	PDGFRL	3.129943	Upregulated
Protein folding
NM_021800.2	DNAJC12	4.182389	Upregulated
Endoplasmic reticulum unfolded protein response
NM_001010990.1	HERPUD1	6.5408597	Upregulated
Regulation of RhoGTPase activity
NM_153213.2	ARHGEF19	2.899712	Upregulated
Regulation of rab GTPase activity
NM_022771.3	TBC1D15	2.361947	Upregulated
NM_020705.1	TBC1D24	3.0267975	Upregulated
Cell-cell signalling
NM_001005914.1	SEMA3B	1.764685	Upregulated
NM_032331.2	MGC2408	2.6944642	Upregulated
NM_001407.1	CELSR3	3.9751458	Upregulated
Translation
NM_181463.1	MRPL55	3.1179419	Upregulated
NM_003136.2	SRP54	2.6215558	Upregulated
Electron transport chain
NM_025147.2	COQ10B	1.7724766	Upregulated
NM_007022.3	CYB561D2	3.542795	Upregulated
Signal transduction
NM_133173.2	APBB3	2.0743015	Upregulated
NM_016115.3	ASB3	2.5060174	Upregulated
Cell proliferation
NM_206825.1	GNL3	4.2791877	Upregulated
DNA replication
NM_017443.3	POLE3	3.112311	Upregulated
Oxidoreductase
NM_017758.2	ALKBH5	3.526197	Upregulated
Microtubule sitoplamic organization
NM_014171.3	CRIPT	2.496879	Upregulated
Growth
NM_031479.3	INHBE	24.436758	Upregulated
Biosynthesis process
NM_014305.1	TGDS	2.4665043	Upregulated
NM_133443.1	GPT2	6.0515475	Upregulated
NM_005768.5	OACT5	2.454743	Downregulated
Modification-dependent protein catabolic process
NM_203301.1	FBXO33	1.5563589	Upregulated
NM_015984.1	UCHL5	2.2333875	Upregulated
Hydrolase activity
NM_203453.2	PPAPDC2	1.8218696	Downregulated
Proteolysis
NM_032549.1	IMMP2L	1.596754	Downregulated