NADPH Oxidase as a Therapeutic Target for Oxalate Induced Injury in Kidneys
Figure 1
Production of ROS and different reactions. ROS with 1 free electron are shown in red and 2 free electrons are shown in blue. ROS, when produced in excess, cause damage to different components of the cell. Excess production of hydrogen peroxide (H2O2) and peroxynitrite () leads to the production of singlet oxygen (1O2). The other radicals shown in the figure are superoxide (), nitric oxide (•NO), nitrogen dioxide (•NO2), hydroxyl radical (•OH), glutathione (GSH), glutathione disulphide (GSSG), thiocyanate (), hypothiocyanous acid (HOSCN), hypochlorous acid (HOCl), and chroramine (R-NHCl). Figure modified from [1, 46].
