The Effect of Alpha-Lipoic Acid on Mitochondrial Superoxide and Glucocorticoid-Induced Hypertension

Table 1

Biological measurements for alpha-lipoic acid studies.

Groups	Thymus (mg/100 g body weight)	Blood glucose (mmol/L)	Plasma NO𝑥 (𝜇M)	Plasma F2-isoprostane (nmol/L)	MitoSOX (geometric MFI)	DiIC1 (5) (geometric MFI)
Saline	127 ± 7.2	11 ± 0.3	9.3 ± 1.2	4.7 ± 0.3	198 ± 15	73 ± 8
DEX	48 ± 4.1*	9 ± 0.4*	12.3 ± 0.9	7.1 ± 0.6*	223 ± 21	107 ± 18
ACTH	48 ± 3.2*	11 ± 0.6	8.2 ± 0.8	5.4 ± 0.4	196 ± 7	110 ± 13
LA + saline p	140 ± 15.8	11 ± 0.6	13.0 ± 1.5	4.9 ± 0.3	201 ± 11	184 ± 12*
LA + DEX p	50 ± 2.0^⋆	10 ± 0.3	11.2 ± 1.0	5.7 ± 0.2^†	220 ± 18	131 ± 8
LA + ACTH p	53 ± 3.7^⋆	10 ± 0.5	13.1 ± 3.4	5.4 ± 0.3	217 ± 13	152 ± 20
HD LA + ACTH p	53 ± 2.1	13 ± 1.1	8.1 ± 1.0	4.6 ± 0.6	273 ± 10^Δ	125 ± 6
Saline + LA r	133 ± 10.0	12 ± 0.5*	12.7 ± 2.3	5.4 ± 0.2	166 ± 18	161 ± 10*
DEX + LA r	52 ± 3.1^#	12 ± 0.8^†	10.9 ± 1.5	5.6 ± 0.5	178 ± 20	134 ± 12

LA: alpha-lipoic acid, HD LA: high dose alpha-lipoic acid, p: prevention, and r: reversal. ^∗𝑃^′<0.05 versus saline, ^⋆𝑃^′<0.005 versus LA + saline prevention, ^#𝑃^′<0.01 versus saline + LA reversal, ^†𝑃^′<0.05 versus DEX, and ^Δ𝑃^′<0.0005 versus ACTH. Data presented as mean ± SEM.