Effects of Endothelial Progenitor Cell-Derived Microvesicles on Hypoxia/Reoxygenation-Induced Endothelial Dysfunction and Apoptosis

Figure 4

Effects of EPC-MVs on miR126 expression, ROS production, and apoptosis in H/R hb-ECs. (a) Representative images showing the merging of PKH26 labeled EPC-MVs with hb-ECs (red: PKH26; blue: DAPI). Scale bar: 100 μm. (b) miR126 expression in H/R hb-ECs cocultured with aEPC-MVs or sEPC-MVs. (c) ROS production of H/R hb-ECs cocultured with aEPC-MVs or sEPC-MVs. (d) Apoptosis of H/R hb-ECs cocultured with aEPC-MVs or sEPC-MVs. *𝑃<0.05, versus vehicle; ⁺𝑃<0.05, versus sEPC-MVs or aEPC-MVs; ^#𝑃<0.05, versus sEPC-MVs or RNase-sEPC-MVs; 𝑁=4/group.

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