Review Article

Pituitary Adenoma Nitroproteomics: Current Status and Perspectives

Table 1

Nitroprotein and unnitrated protein identified from pituitary adenoma [4] and control tissue [3, 16].

Protein namenY site

Pituitary adenoma

Nitrated protein
 Rho-GTPase-activating 5 Q13017 (ARHGAP5)Y550
 Leukocyte immunoglobulin-like receptor A4 P59901 Y404
 Zinc finger protein 432 O94892 Y41
 PKA-beta regulatory subunit [P31321] (PRKAR1B)Y20
 Sphingosine-1-phosphate lyase 1 O95470 Y356
Y366
 Centaurin-beta 1 [Q15027]Y485
 Proteasome subunit alpha type 2 [P25787] (PSMA2)Y228
 Interleukin 1 family member 6 [Q9UHA7] (IL1F6)Y96
 Rhophilin 2 [Q8IUC4] (RHPN2)Y258
Nitroprotein-interacted protein
 Interleukin-1 receptor-associated kinase-like 2 (IRAK-2) O43187 (IRAK2)
 Glutamate receptor-interacting protein 2 [Q9C0E4] (GRIP2)
 Ubiquitin [P629881] (UBB or UBC)

Pituitary control

Nitrated protein
 Synaptosomal-associated protein (SNAP91)Y237
 Ig alpha Fc receptor [P24071] (FCAR)Y223
 Actin [P03996] (ACTA2, ACTG2, and ACTC1)Y296
 PKG 2 [Q13237] (PRKG2)Y354
 Mitochondrial cochaperone protein HscB [Q8IVVL3]Y128
 Stanniocalcin 1 [P52823] (STC1)Y159
 Proteasome subunit alpha type 2 (PSMA2)Y228
 Progestin and adipoQ receptor family member III [Q6TCH7] (PAQR3)Y33

nY: nitrotyrosine. Modified from Zhan and Desiderio [3, 4, 16], with permission from Elsevier Science, copyright 2004, 2006, and 2007.