Neurotoxic Effects of trans-Glutaconic Acid in Rats

Table 2

In vitro effect of trans-glutaconic acid (tGA) on thiobarbituric acid-reactive species (TBA-RS) levels and sulfhydryl (SH) content in mitochondrial preparations from cerebral cortex of 30-day-old rats and glutathione (GSH) content in a commercial GSH preparation.

Group	TBA-RS	SH	GSH
Control	6.44 ± 0.59	55.98 ± 2.30	2941 ± 144.3
1 mM tGA	6.16 ± 0.40	56.22 ± 3.59	2640 ± 70.35

The experiments were performed in triplicate, and data represent mean ± standard error of the mean (𝑛 = 4-5). It was not observed any difference between groups (Student' t-test for paired samples). TBA-RS and SH: nmol · mg of protein⁻¹; GSH: fluorescent unities.