Mild Systemic Oxidative Stress in the Subclinical Stage of Alzheimer’s Disease

Table 1

Oxidative stress parameters in erythrocyte (RBC). Antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), and total glutathione level (TGSH). INT (cognitively intact patients; 𝑛=42) and AD (patients with probable Alzheimer’s disease; 𝑛=23). Values shown correspond to the means ± SEM. Comparison between average results of the groups was performed using Student’s 𝑡-test for independent samples.

Parameter	INT	AD
RBC SOD (U/mg Hb)	7.82±0.24	8.2±0.31
RBC CAT (U/mg Hb)	187±7	184±8
RBC GPx (U/mg Hb)	12.8±0.4	12.6±0.7
RBC TGSH (mmol/Hb)	7.67±0.21	7.45±0.36

𝑃<0.05 was considered significant.