A Regulatory Role of NAD Redox Status on Flavin Cofactor Homeostasis in S. cerevisiae Mitochondria

Figure 9

FAD and NAD homeostasis in SCM. The scheme summarized the functional studies described in this and other previous papers [23, 31, 32, 53]. R₁/R₂, mitochondrial Rf transporter; Flx1p, mitochondrial FAD exporter; Ndt1p/Ndt2p, mitochondrial NAD⁺ transporter; (1), riboflavin kinase (EC 2.7.1.26); (2), FAD synthase (EC 2.7.7.2); (3), FAD pyrophosphatase (EC 3.6.1.18); (4), FMN phosphohydrolase (EC 3.1.3.2); (5), NAD(H) cleaving enzyme; DH, NAD(H)-dependent dehydrogenase; RC, respiratory chain.