Review Article

ALS and Oxidative Stress: The Neurovascular Scenario

Figure 1

The role of hypoxia in stimulating the VEGF through an activation of HIF-1 alpha element. HIF-1 alpha gets activated in deficiency of oxygen in mitochondria leading to creation of oxidative stress. This involves the formation of reactive oxygen species which on reaction with free nitrogen forms NO ultimately leading to reactive nitrogen species (RNS). This RNS further activates NF- B pathway which ultimately leads to activation of HIF-1 alpha factor. The activated form of HIF-1 alpha further leads to VEGF activation thus leading to angiogenesis.
635831.fig.001