Table 2: Cellular localization, activity, and biological function of sirtuins 1–7 according to [63].

SirtuinLocalizationActivityBiological function

Sirt1Nucleus/cytosolDeacetylaseCell survival/metabolism
Sirt2CytosolDeacetylaseCell cycle
Sirt3MitochondriaDeacetylaseThermogenesis/metabolism
Sirt4MitochondriaADP-ribosyltransferaseInsulin secretion/metabolism
Sirt5MitochondriaDeacetylaseUnknown
Sirt6NucleusADP-ribosyltransferaseDNA repair
Sirt7NucleolusUnknownrDNA transcription

ADP: adenosine diphosphate; rDNA: ribosomal desoxyribonucleic acid; Sirt: sirtuin.