Review Article
Nutrition and Healthy Ageing: Calorie Restriction or Polyphenol-Rich “MediterrAsian” Diet?
Table 2
Cellular localization, activity, and biological function of sirtuins 1–7 according to [
63].
| | Sirtuin | Localization | Activity | Biological function |
| | Sirt1 | Nucleus/cytosol | Deacetylase | Cell survival/metabolism | | Sirt2 | Cytosol | Deacetylase | Cell cycle | | Sirt3 | Mitochondria | Deacetylase | Thermogenesis/metabolism | | Sirt4 | Mitochondria | ADP-ribosyltransferase | Insulin secretion/metabolism | | Sirt5 | Mitochondria | Deacetylase | Unknown | | Sirt6 | Nucleus | ADP-ribosyltransferase | DNA repair | | Sirt7 | Nucleolus | Unknown | rDNA transcription |
|
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ADP: adenosine diphosphate; rDNA: ribosomal desoxyribonucleic acid; Sirt: sirtuin.
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