Table 3: Effects of calorie restriction or starvation on Sirt1 in different tissues in mice and rats.

SpeciesNumber animalsCaloric restrictionTissueOutcomeReference

Mice (C57BL6)1040%Muscle, fat 

liver
Sirt1 ↑
(protein)
Sirt1  
(protein)
[66]
Mice
(C57BL/6×C3H/He F1 hybrid)
415%Brain, liver 

heart, muscle
No  effect on  Sirt1 (protein)
Sirt1  
(protein)
[13]
Mice
(C57BL6)
24 h starvationLiverSirt1 ↑
(protein)
no  effect on mRNA
[65]
Mice
(C57BL)
24 h starvationBrain,  heart, muscle,  white  adipose  tissue, and kidneySirt1 ↑
(protein)
no  effect on mRNA
[70]
Mice
(C57BLK/6×SV127 F1 hybrid)
1030–40%White  adipose tissueSirt1 ↑
(protein)
[36]
Mice
(C57BL6)
40%White  adipose tissue, liver, kidney, and brainSirt1 ↑
(protein)
not significant
[71]
Rats
(Fisher 344)
40%Brain,  fat,  kidney, and liverSirt1 ↑
(protein)
[57]