Table 4: Dietary restriction mimetics: mechanisms and side effects.

Name of compoundStructure of compoundMechanism of actionSide effectsReferences

Rapamycin/sirolimus707421.table.001aInhibition of mTor, induction of autophagyImmunosuppression
[93]
2-Deoxy-D-glucose707421.table.001bInhibition of glucose metabolismCardiotoxicity[94]
Metformin707421.table.001cInhibition of gluconeogenesis, stimulation of glucose uptake, inhibition of AMPK, and improvement of insulin sensitivityGastrointestinal complaints[9597]