NRF2-ome: An Integrated Web Resource to Discover Protein Interaction and Regulatory Networks of NRF2

Figure 1

The workflow of the compilation process of NRF2-ome. NRF2-ome is based on the manually curated collection of first neighbor interactors and target genes of NRF2 [5]. The manual curation was extended and complemented with the integration of external databases and predictions on further NRF2 interactors and target genes. The network of TF and miRNA regulators was built upon this interactome and regulome. At this phase, the TFs of miRNAs were also included. Finally, we integrated upstream connections to manually curated signaling pathway from the SignaLink 2 resource.