NRF2-ome: An Integrated Web Resource to Discover Protein Interaction and Regulatory Networks of NRF2
Figure 3
Number of components and interactors in the NRF2-ome database. For each category, darker color indicates the improvement of the dataset compared to the dataset of our earlier publication [5] shown with light color. (a) The number of components (proteins, target genes, TFs, miRNAs, and miRNA regulating TFs) in the NRF2-ome database. (b) The number and type of interactions in the NRF2-ome database. Note the small portion of protein-protein interactions (311) and miRNA-mRNA interactions (64) in the earlier publication [5]. This improvement transforms the originally NRF2-centric (i.e., star-like) dataset into a densely connected network resource. We also note that the earlier publication [5] contained 7,469 target gene IDs, while NRF2-ome contains 7,252 IDs because since then, some of the IDs have been deleted or merged in the Uniprot resource. Thus, there is a slight decrease in the number of target genes in NRF2-ome, but this decrease is coupled with more reliable IDs.
