Major Components of Energy Drinks (Caffeine, Taurine, and Guarana) Exert Cytotoxic Effects on Human Neuronal SH-SY5Y Cells by Decreasing Reactive Oxygen Species Production
Antioxidant enzyme activity and oxidative damage parameters on human neuronal SH-SY5Y cells treated for 2 hours with drug combinations (guarana, caffeine, and taurine). Measurements for SOD (a), CAT (b), GPx (c), GST (d), SH (e), and TBARS (f) at different drug concentrations (mg/mL) are shown. Values are expressed as mean ± SEM of three independent experiments (). Statistical difference compared to control was determined by one-way ANOVA followed by Dunnett’s multiple comparison test (; ; ).