Oxidative Medicine and Cellular Longevity / 2013 / Article / Fig 13

Research Article

Major Components of Energy Drinks (Caffeine, Taurine, and Guarana) Exert Cytotoxic Effects on Human Neuronal SH-SY5Y Cells by Decreasing Reactive Oxygen Species Production

Figure 13

Model for the interactions of ED components through redox/NO and apoptotic pathways. (a) In silico analysis of the interactions of ED components through redox and NO pathways, based on experimental data and database, gave rise to a network model (MEDRI) where exactly 16 compounds (12 ED components, hydrogen peroxide, hydroxyl radicals, molecular oxygen, and nitric oxide) and 144 proteins (87 apoptosis-related and 57 redox/NO-related proteins) interconnected, considering their potential interaction through either “activation,” “inhibition,” “catalysis,” “binding,” or “reaction.” (b) Analysis of the topological network properties by Cytoscape and its 2D projection by ViaComplex Software show in a color-grading representation the areas of maximum values (the closer to red color the higher value) of connectivity, neighborhood connectivity, stress, and clustering coefficient of each node.