Skin Injuries Reduce Survival and Modulate Corticosterone, C-Reactive Protein, Complement Component 3, IgM, and Prostaglandin E₂ after Whole-Body Reactor-Produced Mixed Field (n + 𝜸-Photons) Irradiation

Figure 2

Corticosterone increased then decreased in mouse plasma after irradiation and wounding but not irradiation and burning. 𝑁 = 3–6 per group at each time point. The control corticosterone concentration was 334±24 ng/mL. (a) Skin wound trauma transiently enhanced the radiation-induced increase in plasma corticosterone concentrations at days 1–5 and then reduced it below the baseline at days 5–9. *𝑃<0.05; **𝑃<0.01 versus control group. (b) Skin burn trauma reduced the radiation-induced increase in plasma corticosterone concentrations within 1 d, increased at day 3, reduced again between days 7–9, and returned to the baseline line at day 11. *𝑃<0.05; **𝑃<0.01 versus control group. wnd: wounding; brn: burning; rad: radiation at 3 Gy (n/n + 𝛾 = 0.94).

(a)

(b)