Xenobiotic Sensor- and Metabolism-Related Gene Variants in Environmental Sensitivity-Related Illnesses: A Survey on the Italian Population

Table 3

Haplotype frequencies of CYP2C9, CYP2C19, CYP2D6 and AHR gene variants in SRI patients (MCS: multiple chemical sensitivity; Smcs: suspected multiple chemical sensitivity; other patients: FM/CFS-fibromyalgia/chronic fatigue syndrome).

Haplotype	Haplotype frequency (%)
	MCS	SMCS	Other patients
CYP2C19 Ht*1/*2 - CYP2D6 Ht*1/*4 -; AHR Arg554Lys	9.1	—	—
CYP2C19 Ht*1/*2 - CYP2D6 Ht*1/*4	5.5	1.1	6.25
CYP2C9 Ht*1/*2 - CYP2D6 Ht*1/*41	5.5	—	—
CYP2C9 Ht*1/*2 - CYP2D6 Ht*1/*4	3.6	6.4	—
CYP2C9 Ht*1/*3 - CYP2D6 Ht*1/*4	3.6	2.1	—
CYP2C9 Ht*1/*3 - CYP2D6 Ht*1/*41	3.6	—	—
CYP2C9 Ht*1/*3 - CYP2C19 Ht*1/*2 -; CYP2D6 Ht*1/*4	1.8	—	—
CYP2C9 Ht*1/*3 - CYP2C19 Ht*1/*2 -; CYP2D6 Ht*1/*4 - Arg554Lys	—	—	1.25
CYP2C9 Ht*1/*2 - CYP2C19*1/*2	1.8	—	—
CYP2C9 Ht*1/*2 - CYP2C19 Ht*1/*2 -; AHR Arg554Lys	—	1.1	—
CYP2C9 Ht*1/*2 - CYP2C19 Ht*1/*2 -; CYP2D6 PM*4/*4 - AHR Arg554Lys	—	—	1.25
CYP2C9 Ht*1/*3 - CYP2C19 Ht*1/*2	—	1.1	—
CYP2C9 Ht*1/*2 - CYP2D6 Ht*1/*41 -; AHR Arg554Lys	—	1.1	—
CYP2C19 Ht*1/*2 - CYP2D6 Ht*1/*41	—	1.1	2.5
CYP2C9 Ht*1/*2 - CYP2D6 PM*4/*4	—	1.1	—
CYP2C9 Ht*1/*2 - CYP2D6 PM*4/*41	—	1.1	—
CYP2C9 Ht*1/*2 - CYP2D6 PM*41/*41 -; Arg554Lys	—	—	1.25
CYP2C19 Ht*1/*2 - CYP2D6 PM*4/*4	—	1.1	1.25
CYP2C19 Ht*1/*2 - CYP2D6 PM*4/*4 -; AHR Arg554Lys	—	—	1.25
CYP2C19 Ht*1/*2 - CYP2D6 PM*4/*41	—	2.1	—
CYP2C19 Ht*1/*2 - CYP2D6 PM*41/*41	—	1.1	—
CYP2C9 Ht*1/*3 - CYP2D6 PM*4/*41 -; AHR Arg554Lys	—	—	1.25
CYP2C9 PM*2/*2 - CYP2D6 Ht*1/*41	1.8	—	—
CYP2C9 PM*3/*3 - CYP2C19 PM*2/*2	1.8	—	—
CYP2C9 PM*2/*2 - CYP2D6 PM*4/*41	—	1.1	—
CYP2C9 PM*3/*3 - CYP2D6 PM*41/*41	—	1.1	—
CYP2C19 PM*2/*2 - CYP2D6 Ht*1/*4	—	1.1	—
CYP2C19 PM*2/*2 - CYP2D6 Ht*1/*4 -; AHR Arg554Lys	—	—	1.25