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Oxidative Medicine and Cellular Longevity
Volume 2013, Article ID 848279, 8 pages
http://dx.doi.org/10.1155/2013/848279
Review Article

The Role of the Keap1/Nrf2 Pathway in the Cellular Response to Methylmercury

1Environmental Biology Section, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan
2Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan

Received 28 January 2013; Revised 26 May 2013; Accepted 3 June 2013

Academic Editor: Mi-Kyoung Kwak

Copyright © 2013 Yoshito Kumagai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [30 citations]

The following is the list of published articles that have cited the current article.

  • Emily B. Bisen-Hersh, Marcelo Farina, Fernando Barbosa, Joao B.T. Rocha, and Michael Aschner, “Behavioral Effects of Developmental Methylmercury Drinking Water Exposure in Rodents,” Journal of Trace Elements in Medicine and Biology, 2013. View at Publisher · View at Google Scholar
  • Eiko Yoshida, Yumi Abiko, and Yoshito Kumagai, “Glutathione Adduct of Methylmercury Activates the Keap1–Nrf2 Pathway in SH-SY5Y Cells,” Chemical Research in Toxicology, pp. 141001114041002, 2014. View at Publisher · View at Google Scholar
  • Kento Makino, Kosaku Okuda, Eisuke Sugino, Tadashi Nishiya, Takashi Toyama, Takao Iwawaki, Masatake Fujimura, Yoshito Kumagai, and Takashi Uehara, “Correlation Between Attenuation of Protein Disulfide Isomerase Activity Through S-Mercuration and Neurotoxicity Induced by Methylmercury,” Neurotoxicity Research, 2014. View at Publisher · View at Google Scholar
  • Hironori Kanda, Yoshito Kumagai, and Yasuhiro Shinkai, “S-mercuration of cellular proteins by methylmercury and its toxicological implications,” Journal of Toxicological Sciences, vol. 39, no. 5, pp. 687–700, 2014. View at Publisher · View at Google Scholar
  • Yumi Abiko, Eiko Yoshida, Isao Ishii, Jon M. Fukuto, Takaaki Akaike, and Yoshito Kumagai, “Involvement of Reactive Persulfides in Biological Bismethylmercury Sulfide Formation,” Chemical Research in Toxicology, pp. 150429100632009, 2015. View at Publisher · View at Google Scholar
  • Yumi Abiko, Nho Cong Luong, and Yoshito Kumagai, “A Biotin-PEAC5-maleimide labeling assay to detect electrophiles,” The Journal of Toxicological Sciences, vol. 40, no. 3, pp. 405–411, 2015. View at Publisher · View at Google Scholar
  • Takashi Toyama, Yumi Abiko, Yuko Katayama, Toshiyuki Kaji, and Yoshito Kumagai, “S-Mercuration of ubiquitin carboxyl-terminal hydrolase L1 through Cys152 by methylmercury causes inhibition of its catalytic activity and reduction of monoubiquitin levels in SH-SY5Y cells,” The Journal of Toxicological Sciences, vol. 40, no. 6, pp. 887–893, 2015. View at Publisher · View at Google Scholar
  • Yasuhiro Ishihara, Takuya Takemoto, Atsuhiko Ishida, and Takeshi Yamazaki, “ Protective Actions of 17 β -Estradiol and Progesterone on Oxidative Neuronal Injury Induced by Organometallic Compounds ,” Oxidative Medicine and Cellular Longevity, vol. 2015, pp. 1–16, 2015. View at Publisher · View at Google Scholar
  • Wei Liu, Zhaofa Xu, Tianyao Yang, Bin Xu, Yu Deng, and Shu Feng, “Memantine, a Low-Affinity NMDA Receptor Antagonist, Protects against Methylmercury-Induced Cytotoxicity of Rat Primary Cultured Cortical Neurons, Involvement of Ca2+ Dyshomeostasis Antagonism, and Indirect Antioxidation Effects,” Molecular Neurobiology, 2016. View at Publisher · View at Google Scholar
  • Tianyao Yang, Zhaofa Xu, Wei Liu, Shu Feng, Hongpeng Li, Meixin Guo, Yu Deng, and Bin Xu, “Alpha-lipoic acid reduces methylmercury-induced neuronal injury in rat cerebral cortex via antioxidation pathways,” Environmental Toxicology, 2016. View at Publisher · View at Google Scholar
  • Takamitsu Unoki, Yumi Abiko, Takashi Toyama, Takashi Uehara, Koji Tsuboi, Motohiro Nishida, Toshiyuki Kaji, and Yoshito Kumagai, “Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells,” Scientific Reports, vol. 6, pp. 28944, 2016. View at Publisher · View at Google Scholar
  • Tomoya Fujie, Masaki Murakami, Eiko Yoshida, Tadashi Tachinami, Yasuhiro Shinkai, Yasuyuki Fujiwara, Chika Yamamoto, Yoshito Kumagai, Hiroshi Naka, and Toshiyuki Kaji, “Copper diethyldithiocarbamate as an activator of Nrf2 in cultured vascular endothelial cells,” Journal Of Biological Inorganic Chemistry, vol. 21, no. 2, pp. 263–273, 2016. View at Publisher · View at Google Scholar
  • Yoshito Kumagai, and Yumi Abiko, “Environmental Electrophiles: Protein Adducts, Modulation of Redox Signaling, and Interaction with Persulfides/Polysulfides,” Chemical Research in Toxicology, 2016. View at Publisher · View at Google Scholar
  • Yasuhiro Shinkai, Tomoki Kimura, Ayaka Itagaki, Chika Yamamoto, Keiko Taguchi, Masayuki Yamamoto, Yoshito Kumagai, and Toshiyuki Kaji, “Partial contribution of the Keap1–Nrf2 system to cadmium-mediated metallothionein expression in vascular endothelial cells,” Toxicology and Applied Pharmacology, 2016. View at Publisher · View at Google Scholar
  • Takuya Takemoto, Yasuhiro Ishihara, Mayumi Tsuji, Toshihiro Kawamoto, and Takeshi Yamazaki, “Transcription factor activation in rat primary astrocytes exposed to methylmercury,” Fundamental Toxicological Sciences, vol. 3, no. 2, pp. 63–65, 2016. View at Publisher · View at Google Scholar
  • Motohiro Nishida, Yoshito Kumagai, Hideshi Ihara, Shigemoto Fujii, Hozumi Motohashi, and Takaaki Akaike, “Redox signaling regulated by electrophiles and reactive sulfur species,” Journal of Clinical Biochemistry and Nutrition, 2016. View at Publisher · View at Google Scholar
  • Hongmei Chen, Xuexi Tang, Bin Zhou, Zhongyuan Zhou, Ningning Xu, and You Wang, “A ROS-mediated Mitochondrial Pathway and Nrf2 Pathway Activation Are Involved in BDE-47 Induced Apoptosis in Neuro-2a Cells,” Chemosphere, 2017. View at Publisher · View at Google Scholar
  • Min-Soek Kim, Tsutomu Takahashi, Jin-Yong Lee, Nobuhiko Miura, Masato Asanuma, Gi-Wook Hwang, and Akira Naganuma, “Identification of transcription factors activated by methylmercury in mouse brain,” Fundamental Toxicological Sciences, vol. 4, no. 1, pp. 37–39, 2017. View at Publisher · View at Google Scholar
  • Takamitsu Unoki, Masahiro Akiyama, Yoshito Kumagai, Filipe Marques Gonçalves, Marcelo Farina, João Batista Teixeira da Rocha, and Michael Aschner, “Molecular Pathways Associated With Methylmercury-Induced Nrf2 Modulation,” Frontiers in Genetics, vol. 9, 2018. View at Publisher · View at Google Scholar
  • Alessandra Antunes dos Santos, Beatriz Ferrer, Filipe Marques Gonçalves, Aristides Tsatsakis, Elisavet Renieri, Anatoly Skalny, Marcelo Farina, João Rocha, and Michael Aschner, “Oxidative Stress in Methylmercury-Induced Cell Toxicity,” Toxics, vol. 6, no. 3, pp. 47, 2018. View at Publisher · View at Google Scholar
  • Joanna A. Ruszkiewicz, Adi Pinkas, Mahfuzur R. Miah, Rebecca L. Weitz, Michael J.A. Lawes, Ayodele J. Akinyemi, Omamuyovwi M. Ijomone, and Michael Aschner, “C. elegans as a model in developmental neurotoxicology,” Toxicology and Applied Pharmacology, 2018. View at Publisher · View at Google Scholar
  • Wei Liu, Tianyao Yang, Zhaofa Xu, Bin Xu, and Yu Deng, “Methyl-mercury induces apoptosis through ROS-mediated endoplasmic reticulum stress and mitochondrial apoptosis pathways activation in rat cortical neurons,” Free Radical Research, pp. 1–19, 2018. View at Publisher · View at Google Scholar
  • Tao Ke, Filipe Marques Gonçalves, Cinara Ludvig Gonçalves, Alessandra Antunes dos Santos, João B.T. Rocha, Marcelo Farina, Anatoly Skalny, Aristidis Tsatsakis, Aaron B. Bowman, and Michael Aschner, “Post-translational modifications in MeHg-induced neurotoxicity,” Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2018. View at Publisher · View at Google Scholar
  • Shubhangi Chauhan, Kriya Dunlap, and Lawrence K. Duffy, “Effects of Methylmercury and Theaflavin Digallate on Adipokines in Mature 3T3-L1 Adipocytes,” International Journal of Molecular Sciences, vol. 20, no. 11, pp. 2755, 2019. View at Publisher · View at Google Scholar
  • Masahiro Akiyama, Takamitsu Unoki, Yasuhiro Shinkai, Isao Ishii, Tomoaki Ida, Takaaki Akaike, Masayuki Yamamoto, and Yoshito Kumagai, “Environmental Electrophile-Mediated Toxicity in Mice Lacking Nrf2, CSE, or Both,” Environmental Health Perspectives, vol. 127, no. 6, pp. 067002, 2019. View at Publisher · View at Google Scholar
  • Dan Li, Lingtian Xie, Michael J. Carvan, and Laodong Guo, “Mitigative effects of natural and model dissolved organic matter with different functionalities on the toxicity of methylmercury in embryonic zebrafish,” Environmental Pollution, 2019. View at Publisher · View at Google Scholar
  • Chang Jie, Zhou Yun, Wang Qiang, Michael Aschner, and Lu Rongzhu, “Plant components can reduce methylmercury toxication: A mini-review,” Biochimica et Biophysica Acta (BBA) - General Subjects, 2019. View at Publisher · View at Google Scholar
  • Yasukazu Takanezawa, Ryosuke Nakamura, Miho Hamaguchi, Kanae Yamamoto, Yuka Sone, Shimpei Uraguchi, and Masako Kiyono, “Docosahexaenoic acid enhances methylmercury-induced endoplasmic reticulum stress and cell death and eicosapentaenoic acid potentially attenuates these effects in mouse embryonic fibroblasts,” Toxicology Letters, 2019. View at Publisher · View at Google Scholar
  • Pablo A. Nogara, Cláudia S. Oliveira, Gabriela L. Schmitz, Paulo C. Piquini, Marcelo Farina, Michael Aschner, and João B.T. Rocha, “Methylmercury’s chemistry: from the environment to the mammalian brain,” Biochimica et Biophysica Acta (BBA) - General Subjects, 2019. View at Publisher · View at Google Scholar
  • Kewin Gombeau, Ricardo Bezerra de Oliveira, Sandra Layse Ferreira Sarrazin, Rosa Helena Veras Mourão, and Jean-Paul Bourdineaud, “ Protective Effects of Plathymenia reticulata and Connarus favosus Aqueous Extracts against Cadmium- and Mercury-Induced Toxicities ,” Toxicological Research, vol. 35, no. 1, pp. 25–35, 2019. View at Publisher · View at Google Scholar