A Novel Tetrapeptide Derivative Exhibits In Vitro Inhibition of Neutrophil-Derived Reactive Oxygen Species and Lysosomal Enzymes Release

Figure 2

Effect of PEP1261 on myocardial infarct rat neutrophils ROS generation. All values are mean ± SD (𝑛=20). H₂O₂ level was expressed as 𝜇moles of H₂O₂ liberated/0.5×10⁶ cells. O₂^•− level was expressed as nmoles of O₂⁻ liberated/min/mg protein. MPO level was expressed as μmoles of H₂O₂ utilized/min/mg protein. NS = nonsignificant as compared to control; **𝑃<0.01 as compared to control; ^##𝑃<0.01 as compared to PMA stimulated cells; ^$$𝑃<0.01 as compared to rat myocardial infarct cells.