Chloroquine Interference with Hemoglobin Endocytic Trafficking Suppresses Adaptive Heme and Iron Homeostasis in Macrophages: The Paradox of an Antimalarial Agent

<table>SRM of Hb peptides. (a) Amino acid sequences of the alpha and beta chains of Hb. The selected peptides are indicated as bold text (one peptide in the alpha chain, two peptides in the beta chain). (b) Elution chromatography profiles of the three Hb peptides (SAVTALWGK, MFLSFPTTK, and LLVVYPWTQR). (c) Transition profiles of precursor and fragment ions of SAVTALWGK peptide coeluting at 32.96 min. </table>

Oxidative Medicine and Cellular Longevity

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Figure 1

Figure 1: Chloroquine Interference with Hemoglobin Endocytic Trafficking Suppresses Adaptive Heme and Iron Homeostasis in Macrophages: The Paradox of an Antimalarial Agent 

Figure 1 | Chloroquine Interference with Hemoglobin Endocytic Trafficking Suppresses Adaptive Heme and Iron Homeostasis in Macrophages: The Paradox of an Antimalarial Agent 