Oxidative Medicine and Cellular Longevity

Research Article

Oxidant-Antioxidant Balance in the Blood of Patients with Chronic Obstructive Pulmonary Disease After Smoking Cessation

Table 4

Enzyme activity and the levels of antioxidant vitamins in the COPD patients who had given up smoking and in the representatives of the control groups: COPD patients who had not given up smoking and healthy subjects.


Group	Parameters
Group	SOD (U/g Hb)	GPx (U/g Hb)	CAT (10⁴ IU/g Hb)	Vit. A (μg/L)	Vit. E (10² μg/L)

Control I (healthy nonsmokers)	1114.7 ± 176.9	13.8 ± 4.6	57.6 ± 9.9	325.3 ± 98.2	30.2 ± 6.4

COPD patients who had not given up smoking (Control II)
At the beginning of the study	1606.2 ± 501.0**	8.8 ± 3.1***	53.9 ± 13.2	279.0 ± 89.1	25.0 ± 9.4
After the 1st month of the study	1585.8 ± 472.7**	8.6 ± 4.1***	53.2 ± 12.1	277.3 ± 96.0	24.6 ± 8.1
After the 2nd month of the study	1723.2 ± 439.4***	7.8 ± 3.3***	51.3 ± 15.4	273.7 ± 93.3	19.3 ± 8.4***
After the 3rd month of the study	1747.5 ± 478.8***	7.8 ± 3.0***	50.3 ± 19.8	272.0 ± 86.8	18.9 ± 6.9***

COPD patients who had given up smoking (study group)
Before smoking cessation	1564.3 ± 581.1*	8.2 ± 3.1***	53.7 ± 12.9	275.8 ± 88.4	25.8 ± 8.0
After the 1st month of tobacco abstinence	1511.0 ± 700.8*	8.2 ± 3.8***	54.5 ± 13.1	295.0 ± 100.9	28.8 ± 14.0^ccddd
After the 2nd month of tobacco abstinence	1506.7 ± 630.9	9.2 ± 3.2***	55.1 ± 14.9	313.7 ± 109.9	29.2 ± 11.6^cccddd
After the 3rd month of tobacco abstinence	1117.4 ± 343.6^{aabbcccdddeeffg}		56.3 ± 14.7	315.2 ± 106.2	29.7 ± 9.9^cccddd

COPD: chronic obstructive pulmonary disease; SOD: superoxide dismutase; GPx: glutathione peroxidase; CAT: catalase; Vit. E, A: vitamins E, A.
Data expressed as mean .
Statistically significant differences versus Control I: *P < 0.05, **P < 0.01, and ***P < 0.001; versus
Control II at the beginning of the study: ^aaP < 0.01; versus Control II after the 1st month: ^bbP < 0.01; versus Control II after the 2nd month: ^ccP < 0.01, ^cccP < 0.001; versus Control II after the 3rd month: ^ddP < 0.01, ^dddP < 0.001; versus the study group before smoking cessation: ^eeP < 0.01; versus the study group after the 1st month of tobacco abstinence: ^ffP < 0.01; versus the study group after the 2nd month of tobacco abstinence: ^gP < 0.05.