The Influence of Nrf2 on Cardiac Responses to Environmental Stressors

Table 1

Pairwise comparisons for overall effects between three-way ANOVA factors for heart rate (HR) and heart rate variability (HRV) responses to ultrafine particulate matter (UF-PM) or saline control.

	Difference between means	Direction of difference between means	q value	P value
HR responses to UF-PM or saline
Comparison: treatment within 𝑁𝑟𝑓2^−/−
UF-PM versus saline	21.26 bpm	UF-PM > saline	5.27	<0.001
Comparison: genotype within UF-PM
𝑁𝑟𝑓2^−/− versus 𝑁𝑟𝑓2^+/+	24.29 bpm	𝑁𝑟𝑓2^−/−>𝑁𝑟𝑓2^+/+	6.06	<0.001
LF HRV responses to UF-PM or saline
Comparisons: treatment
saline versus UF-PM	0.02 ms^2/Hz	Saline > UF-PM	2.79	0.048
HF HRV responses to UF-PM or saline
Comparison: treatment
UF-PM versus saline	0.13 ms^2/Hz	UF-PM > saline	4.39	0.002
Comparison: treatment within 𝑁𝑟𝑓2^−/−
UF-PM versus saline	0.37 ms^2/Hz	UF-PM > saline	9.04	<0.001
Comparison: genotype within saline
𝑁𝑟𝑓2^−/− versus 𝑁𝑟𝑓2^+/+	0.15 ms^2/Hz	𝑁𝑟𝑓2^+/+>𝑁𝑟𝑓2^−/−	3.32	0.019
Comparison: genotype within UF-PM
𝑁𝑟𝑓2^−/− versus 𝑁𝑟𝑓2^+/+	0.33 ms^2/Hz	𝑁𝑟𝑓2^−/−>𝑁𝑟𝑓2^+/+	8.06	<0.001
TP HRV responses to UF-PM or saline
Comparison: treatment within 𝑁𝑟𝑓2^+/+
saline versus UF-PM	0.17 ms^2/Hz	saline > UF-PM	3.78	0.007
Comparison: treatment within 𝑁𝑟𝑓2^−/−
UF-PM versus saline	0.35 ms^2/Hz	UF-PM > saline	8.22	<0.001
Comparison: genotype within saline
𝑁𝑟𝑓2^−/− versus 𝑁𝑟𝑓2^+/+	0.19 ms^2/Hz	𝑁𝑟𝑓2^+/+>𝑁𝑟𝑓2^−/−	4.06	0.004
Comparison: genotype within UF-PM
𝑁𝑟𝑓2^−/− versus 𝑁𝑟𝑓2^+/+	0.34 ms^2/Hz	𝑁𝑟𝑓2^−/−>𝑁𝑟𝑓2^+/+	7.93	<0.001