Adduct of Malondialdehyde to Hemoglobin: A New Marker of Oxidative Stress That Is Associated with Significant Morbidity in Preterm Infants
Table 1
Characteristics of 83 very preterm infants with (ISM+) or without (ISM−) composite index of severe morbidity (ISM).
All
ISM+
ISM−
value*
Singleton, (%)
62 (74.7)
14 (82.3)
48 (72.7)
0.07
Antenatal steroids, (%)
74 (89.1)
14 (88.3)
60 (90.9)
0.38
Fetal growth restriction, (%)
11 (13.3)
1 (5.9)
10 (15.2)
0.45
Preeclampsia, (%)
10 (12)
0 (0)
10 (15.2)
0.11
Maternal antenatal infection, (%)
5 (6.0)
1 (5.9)
4 (6.1)
1.00
Others causes, (%)
57 (68.7)
15 (88.2)
42 (63.6)
0.08
Cesarean section, (%)
50 (62.6)
7 (41.2)
45 (68.2)
0.05
Gestational age at birth, weeks
28.7 (24.0–31.6)
26.0 (24.0–30.4)
29.0 (24.5–31.6)
<0.01
Birth weight, grams
1085 (570–1500)
765 (570–1500)
1120 (690–1500)
<0.01
Male, (%)
39 (47.0)
11 (64.7)
28 (44.4)
0.10
Apgar score at 5 min, value
9 (2–10)
8 (6–10)
9 (2–10)
0.09
Resuscitation in DR, (%)
49 (59.0)
14 (82.4)
35 (53.0)
0.08
RDS, (%)
80 (96.4)
17 (100.0)
63 (95.5)
0.37
Surfactant, (%)
51 (61.4)
14 (82.3)
37 (56.0)
0.03
Oxygen therapy, hours
37 (1–1661)
276 (1–1661)
68 (1–948)
<0.01
Assisted ventilation, hours
64 (1–1107)
427 (5–1107)
27 (1–764)
<0.01
Early onset sepsis, (%)
6 (7.2)
4 (23.5)
2 (3.0)
0.01
Late onset sepsis, (%)
22 (26.5)
10 (58.8)
12 (18.2)
<0.01
Persistent ductus arteriosus, (%)
22 (26.5)
8 (47.0)
14 (21.2)
0.03
Blood transfusions, (%)
34 (41.0)
14 (82.3)
20 (30.3)
<0.01
Parenteral nutrition, (%)
63 (75.9)
15 (88.2)
48 (72.7)
<0.01
Parenteral nutrition duration, d
8 (1–35)
13 (1–35)
9 (1–28)
<0.01
Categorical variables are presented as number (%) and continuous variables as median (min–max).
*Comparison between the 2 groups (ISM+ versus ISM−, Mann-Whitney or Chi2 test).
