Nrf2 Is Crucial to Graft Survival in a Rodent Model of Heart Transplantation
Figure 2
Nrf2 IHC staining in donor Balb/c hearts 2 days following transplant. Formalin-fixed and paraffin-embedded heart from donor Balb/c mice were analyzed for Nrf2 expression two days after heart transplant. Nrf2 levels are moderate as shown by minimal nuclear staining in the C57BL/6 recipient Nrf2 WT (a) and KO (b) groups. Treatment of C57BL/6 recipient Nrf2 WT with SF (c) increases nuclear expression of Nrf2 in donor. Arrowheads denote positive nuclear staining.
