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Oxidative Medicine and Cellular Longevity
Volume 2014, Article ID 103068, 7 pages
Review Article

Involvement of miRNAs in Placental Alterations Mediated by Oxidative Stress

1Department of Biomolecular Sciences, University of Urbino, Via Saffi 2, 61029 Urbino, Italy
2Department of Molecular and Developmental Medicine, University of Siena, Viale Bracci, 36, 53100 Siena, Italy

Received 23 October 2013; Revised 19 January 2014; Accepted 13 February 2014; Published 18 March 2014

Academic Editor: Rønnaug Solberg

Copyright © 2014 Alexander Rudov et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Oxidative stress (OS) is known to be strongly involved in a large number of fetal, neonatal, and adult diseases, including placental disorders, leading to pregnancy loss and stillbirths. A growing body of research links OS to preeclampsia, gestational diabetes, obesity, spontaneous abortion, recurrent pregnancy, preterm labor, and intrauterine growth restriction. While a considerable number of miRNAs have been related to physiological functions and pathological conditions of the placenta, a direct link among these miRNAs, placental functions, and OS is still lacking. This review summarizes data describing the role of miRNAs in placental pathophysiological processes and their possible impact on OS damaging responses. As miRNAs can be found in circulation, improving our understanding on their role in the pathogenesis of pregnancy related disorders could have an important impact on the diagnosis and prognosis of these diseases.