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Oxidative Medicine and Cellular Longevity
Volume 2014, Article ID 135650, 10 pages
http://dx.doi.org/10.1155/2014/135650
Research Article

Indices of Paraoxonase and Oxidative Status Do Not Enhance the Prediction of Subclinical Cardiovascular Disease in Mixed-Ancestry South Africans

1Division of Chemical Pathology, Faculty of Health Sciences, National Health Laboratory Service (NHLS) and University of Stellenbosch, Cape Town, South Africa
2NCRP for Cardiovascular and Metabolic Diseases, South African Medical Research Council & and University of Cape Town, Cape Town, South Africa
3Division of Chemical Pathology, University of Cape Town, Cape Town, South Africa
4Department of Biomedical Sciences, Faculty of Health and Wellness Science, Cape Peninsula University of Technology, P.O. Box 1906, Bellville, Cape Town 7530, South Africa

Received 30 September 2013; Accepted 2 March 2014; Published 27 March 2014

Academic Editor: Dalton Valentim Vassallo

Copyright © 2014 M. Macharia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. World Health Organization, Prevention of Cardiovascular Disease: Guidelines for Assessment and Management of Total Cardiovascular Risk, World Health Organization, Geneva, Switzerland, 2007.
  2. S. A. Matheus, L. R. M. Tannus, R. A. Cobas, C. C. S. Palma, C. A. Negrato, and M. B. Gomes, “Impact of diabetes on cardiovascular disease: an update,” International Journal of Hypertension, vol. 2013, Article ID 653789, 15 pages, 2013. View at Publisher · View at Google Scholar
  3. M. K. Ali, K. M. V. Narayan, and N. Tandon, “Diabetes & coronary heart disease: current perspectives,” Indian Journal of Medical Research, vol. 132, no. 11, pp. 584–597, 2010. View at Google Scholar · View at Scopus
  4. P. Poirier, T. D. Giles, G. A. Bray et al., “Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on obesity and heart disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism,” Circulation, vol. 113, no. 6, pp. 898–918, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. I. Bondia-Pons, L. Ryan, and J. A. Martinez, “Oxidative stress and inflammation interactions in human obesity,” Journal of Physiology and Biochemistry, vol. 68, pp. 701–711, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Logue, H. M. Murray, P. Welsh et al., “Obesity is associated with fatal coronary heart disease independently of traditional risk factors and deprivation,” Heart, vol. 97, no. 7, pp. 564–568, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. B. Dursun, E. Dursun, G. Suleymanlar et al., “Carotid artery intima-media thickness correlates with oxidative stress in chronic haemodialysis patients with accelerated atherosclerosis,” Nephrology Dialysis Transplantation, vol. 23, no. 5, pp. 1697–1703, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. H. A. Labib, R. L. Etewa, O. A. Gaber, M. Atfy, T. M. Mostafa, and I. Barsoum, “Paraoxonase-1 and oxidative status in common Mediterranean β-thalassaemia mutations trait, and their relations to atherosclerosis,” Journal of Clinical Pathology, vol. 64, no. 5, pp. 437–442, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. R. Norman, D. Bradshaw, M. Schneider, D. Pieterse, and P. Groenwald, Revised Burden of Disease Estimates for fhe Comparative Risk Factor Assessment, South Africa 2000, Medical Research Council, Cape Town, South Africa, 2006.
  10. R. T. Erasmus, D. J. Soita, M. S. Hassan et al., “High prevalence of diabetes mellitus and metabolic syndrome in a South African coloured population: baseline data of a study in Bellville, Cape Town,” South African Medical Journal, vol. 102, no. 11, part 1, pp. 841–844, 2012. View at Publisher · View at Google Scholar
  11. T. E. Matsha, M. S. Hassan, M. Kidd, and R. T. Erasmus, “The 30-year cardiovascular risk profile of South Africans with diagnosed diabetes, undiagnosed diabetes, pre-diabetes or normoglycaemia: the Bellville, South Africa pilot study,” Cardiovascular Journal of Africa, vol. 23, no. 1, pp. 5–11, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. E. de Wit, W. Delport, C. E. Rugamika et al., “Genome-wide analysis of the structure of the South African Coloured Population in the Western Cape,” Human Genetics, vol. 128, no. 2, pp. 145–153, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Chalmers, S. MacMahon, G. Mancia et al., “1999 World Health Organization-International Society of Hypertension Guidelines for the management of hypertension. Guidelines sub-committee of the World Health Organization,” vol. 21, no. 5-6, pp. 1009–1060, 1999. View at Google Scholar
  14. K. G. Alberti and P. Z. Zimmet, “Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation,” Diabetic Medicine, vol. 15, no. 7, pp. 539–553, 1998. View at Google Scholar
  15. W. T. Friedewald, R. I. Levy, and D. S. Fredrickson, “Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge,” Clinical Chemistry, vol. 18, no. 6, pp. 499–502, 1972. View at Google Scholar · View at Scopus
  16. I. F. F. Benzie and J. J. Strain, “The ferric reducing ability of plasma (FRAP) as a measure of 'antioxidant power': the FRAP assay,” Analytical Biochemistry, vol. 239, no. 1, pp. 70–76, 1996. View at Publisher · View at Google Scholar · View at Scopus
  17. R. Re, N. Pellegrini, A. Proteggente, A. Pannala, M. Yang, and C. Rice-Evans, “Antioxidant activity applying an improved ABTS radical cation decolorization assay,” Free Radical Biology and Medicine, vol. 26, no. 9-10, pp. 1231–1237, 1999. View at Publisher · View at Google Scholar · View at Scopus
  18. R. J. Richter and C. E. Furlong, “Determination of paraoxonase (PON1) status requires more than genotyping,” Pharmacogenetics, vol. 9, no. 6, pp. 745–753, 1999. View at Google Scholar · View at Scopus
  19. R. W. Browne, S. T. Koury, S. Marion, G. Wilding, P. Muti, and M. Trevisan, “Accuracy and biological variation of human serum paraoxonase 1 activity and polymorphism (Q192R) by kinetic enzyme assay,” Clinical Chemistry, vol. 53, no. 2, pp. 310–317, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. A. M. Jentzsch, H. Bachmann, P. Fürst, and H. K. Biesalski, “Improved analysis of malondialdehyde in human body fluids,” Free Radical Biology and Medicine, vol. 20, no. 2, pp. 251–256, 1996. View at Publisher · View at Google Scholar · View at Scopus
  21. G. E. P. Box and D. R. Cox, “An analysis of transformations,” Journal of the Royal Statistical Society B: Statistical Methodology, vol. 26, no. 2, pp. 211–252, 1964. View at Google Scholar
  22. J. T. Kent, D. E. Tyler, and Y. A. Vardi, “Curious likelihood identity for the multivariate t-distribution,” Communications in Statistics-Simulation and Computation, vol. 23, no. 2, pp. 441–453, 1994. View at Publisher · View at Google Scholar
  23. M. I. Mackness, S. Arrol, and P. N. Durrington, “Paraoxonase prevents accumulation of lipoperoxides in low-density lipoprotein,” FEBS Letters, vol. 286, no. 1-2, pp. 152–154, 1991. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Rosenblat, L. Gaidukov, O. Khersonsky et al., “The catalytic histidine dyad of high density lipoprotein-associated serum paraoxonase-1 (PON1) is essential for PON1-mediated inhibition of low density lipoprotein oxidation and stimulation of macrophage cholesterol efflux,” Journal of Biological Chemistry, vol. 281, no. 11, pp. 7657–7665, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. B. Mackness, P. Durrington, P. McElduff et al., “Low paraoxonase activity predicts coronary events in the Caerphilly Prospective Study,” Circulation, vol. 107, no. 22, pp. 2775–2779, 2003. View at Publisher · View at Google Scholar · View at Scopus
  26. C. A. Abbott, M. I. Mackness, S. Kumar, A. J. Boulton, and P. N. Durrington, “Serum paraoxonase activity, concentration, and phenotype distribution in diabetes mellitus and its relationship to serum lipids and lipoproteins,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 15, no. 11, pp. 1812–1818, 1995. View at Google Scholar · View at Scopus
  27. L. Bajnok, I. Seres, Z. Varga et al., “Relationship of serum resistin level to traits of metabolic syndrome and serum paraoxonase 1 activity in a population with a broad range of body mass index,” Experimental and Clinical Endocrinology and Diabetes, vol. 116, no. 10, pp. 592–599, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Inoue, T. Suehiro, T. Nakamura, Y. Ikeda, Y. Kumon, and K. Hashimoto, “Serum arylesterase/diazoxonase activity and genetic polymorphisms in patients with type 2 diabetes,” Metabolism: Clinical and Experimental, vol. 49, no. 11, pp. 1400–1405, 2000. View at Publisher · View at Google Scholar · View at Scopus
  29. C. Y. Han, T. Chiba, J. S. Campbell et al., “Reciprocal and coordinate regulation of serum amyloid A versus apolipoprotein A-I and paraoxonase-1 by inflammation in murine hepatocytes,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 26, no. 8, pp. 1806–1813, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. Y. Kumon, Y. Nakauchi, T. Suehiro et al., “Proinflammatory cytokines but not acute phase serum amyloid A or C-reactive protein, downregulate paraoxonase 1 (PON1) expression by HepG2 cells,” Amyloid, vol. 9, no. 3, pp. 160–164, 2002. View at Google Scholar · View at Scopus
  31. K. R. Feingold, R. A. Memon, A. H. Moser, and C. Grunfeld, “Paraoxonase activity in the serum and hepatic mRNA levels decrease during the acute phase response,” Atherosclerosis, vol. 139, no. 2, pp. 307–315, 1998. View at Publisher · View at Google Scholar · View at Scopus
  32. M. Aviram, M. Rosenblat, S. Billecke et al., “Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants,” Free Radical Biology and Medicine, vol. 26, no. 7-8, pp. 892–904, 1999. View at Publisher · View at Google Scholar · View at Scopus
  33. V. Mohamed-Ali, L. Flower, J. Sethi et al., “β-adrenergic regulation of IL-6 release from adipose tissue: in vivo and in vitro studies,” Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 12, pp. 5864–5869, 2001. View at Publisher · View at Google Scholar · View at Scopus
  34. G. Ferretti, T. Bacchetti, C. Moroni et al., “Paraoxonase activity in high-density lipoproteins: a comparison between healthy and obese females,” Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 3, pp. 1728–1733, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. U. N. Khot, M. B. Khot, C. T. Bajzer et al., “Prevalence of conventional risk factors in patients with coronary heart disease,” Journal of the American Medical Association, vol. 290, no. 7, pp. 898–904, 2003. View at Publisher · View at Google Scholar · View at Scopus
  36. P. Greenland, M. D. Knoll, J. Stamler et al., “Major risk factors as antecedents of fatal and nonfatal coronary heart disease events,” Journal of the American Medical Association, vol. 290, no. 7, pp. 891–897, 2003. View at Publisher · View at Google Scholar · View at Scopus
  37. D. S. Ng, T. Chu, B. Esposito, P. Hui, P. W. Connelly, and P. L. Gross, “Paraoxonase-1 deficiency in mice predisposes to vascular inflammation, oxidative stress, and thrombogenicity in the absence of hyperlipidemia,” Cardiovascular Pathology, vol. 17, no. 4, pp. 226–232, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. L. M. Browning, S. D. Hsieh, and M. Ashwell, “A systematic review of waist-to-height ratio as a screening tool for the prediction of cardiovascular disease and diabetes: 0.5 could be a suitable global boundary value,” Nutrition Research Reviews, vol. 23, no. 2, pp. 247–269, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. B. Palmieri and V. Sblendorio, “Oxidative stress tests: overview on reliability and use—part I,” European Review for Medical and Pharmacological Sciences, vol. 11, no. 5, pp. 309–342, 2007. View at Google Scholar · View at Scopus