Dietary Lycium barbarum Polysaccharide Induces Nrf2/ARE Pathway and Ameliorates Insulin Resistance Induced by High-Fat via Activation of PI3K/AKT Signaling

Figure 1

LBP prevents HFD-induced insulin resistance and modulates glucose metabolism in vivo. Injected intraperitoneal (a) glucose tolerance test, (b) insulin tolerance test, and (c) pyruvate tolerance test. Down: area under the curve (AUC). All data were expressed as means ± SEM (𝑛=6 per group), ^#𝑃<0.05. (d) The mRNA levels of GCK, PK, PEPCK, and G6Pase were analyzed by qRT-PCR. Data was expressed as means ± SEM (𝑛=3 per group), ^#𝑃<0.05. (e) GCK and (f) PK activities were measured with enzymatic colorimetric activity kits. Data was expressed as means ± SEM (𝑛=6 per group), ^#𝑃<0.05. LBPH, 100 mg/kg LBP plus high-fat diet.

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