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Oxidative Medicine and Cellular Longevity
Volume 2014, Article ID 154295, 7 pages
Research Article

Effect of Centella asiatica on Oxidative Stress and Lipid Metabolism in Hyperlipidemic Animal Models

1Medical College, Xiamen University, Xiang’an District, Xiamen 361000, China
2Xiamen Key Laboratory of Chiral Drugs, Xiamen 361000, China
3College of Pharmacy, Hubei University of Science and Technology, Xianning 437000, China

Received 14 February 2014; Revised 29 March 2014; Accepted 1 April 2014; Published 16 April 2014

Academic Editor: Si Jin

Copyright © 2014 Yun Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hyperlipidemia and many other metabolic diseases are related to oxidative stress. Centella asiatica is a traditional Chinese medicine whose antioxidant effect in vitro has been reported. We are interested in whether it possesses this effect in vivo and hence modulates lipid metabolism. Therefore, experiments were carried out on mice and golden hamsters regarding its antioxidant and hypolipidemic effect. We observed that a fraction (CAF3) of the ethanol extract (CAE) of Centella asiatica had a cholesterol decrease of 79% and a triglyceride decrease of 95% in acute mice model, so CAF3 was further investigated in high-fat-fed hamster model. It was shown that CAF3 increased SOD and GSH-Px activities and decreased MDA level, and it also improved TC, TG, LDL-C, HDL-C, AST, and ALT levels. L-CAT and SR-BI gene expression in hamsters were increased. Taken together, our data suggest that the CAF3 fraction of Centella asiatica has antioxidant and hypolipidemic properties.