PELP1 Suppression Inhibits Colorectal Cancer through c-Src Downregulation

Figure 4

PELP1 silencing suppressed CRC through c-Src downregulation. (a) PELP1 silencing was accompanied by the downregulation of c-Src mRNA as determined by quantitative RT-PCR. (b) PELP1 silencing was accompanied by c-Src protein downregulation as determined by western blot. (c) Decreased cell viability induced by PELP1 silencing was recovered by c-Src upregulation in HT-29. (d) Decreased colony formation ability was recovered by c-Src upregulation in HT-29. (e) Decreased migration ability was recovered by c-Src upregulation in HT-29. (f) Decreased invasion ability was recovered by c-Src upregulation in HT-29. (g) Induced senescence by PELP1 silencing was inhibited after c-Src upregulation.