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Oxidative Medicine and Cellular Longevity
Volume 2014, Article ID 203458, 7 pages
http://dx.doi.org/10.1155/2014/203458
Research Article

Magnolin Protects against Contrast-Induced Nephropathy in Rats via Antioxidation and Antiapoptosis

1Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Road, Shanghai 200233, China
2Department of Urology, Shanghai Jiao Tong University Affiliated First People’s Hospital, 100 Haining Road, Shanghai 200080, China
3Department of Nephrology, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin 150001, China
4Florey Institute of Neuroscience and Mental Health, University of Melbourne, VIC 3010, Australia

Received 2 August 2014; Accepted 1 October 2014; Published 21 October 2014

Academic Editor: Daniela Giustarini

Copyright © 2014 Feng Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Magnolin is the major active ingredient of the herb Magnolia fargesii which has anti-inflammatory and antioxidative effects. Oxidative stress and apoptosis are involved in the pathogenesis of contrast-induced nephropathy (CIN). We hypothesize that Magnolin could protect against CIN through antioxidative and antiapoptotic properties. Methods. To test whether Magnolin could attenuate CIN, oxidative stress and apoptosis, in vivo and in vitro, we utilized a rat model of ioversol-induced CIN and a cell model of oxidative stress in which HK2 cells were treated with H2O2. Rats were assigned to 4 groups ( per group): control group, ioversol group (ioversol-induced CIN), vehicle group (CIN rats pretreated with vehicle), and Magnolin group (CIN rats pretreated with 1 mg/kg Magnolin). Results. The results showed that magnolin ameliorated the renal tubular necrosis, apoptosis, and the deterioration of renal function (). Furthermore, Magnolin reduced the renal oxidative stress, suppressed caspase-3 activity, and increased Bcl-2 expression in vivo and in vitro. Conclusion. Magnolin might protect CIN in rats through antioxidation and antiapoptosis.