Magnolia Extract (BL153) Protection of Heart from Lipid Accumulation Caused Cardiac Oxidative Damage, Inflammation, and Cell Death in High-Fat Diet Fed Mice

Figure 1

The effects of BL153 on body weight, energy intake, heart weight, and lung weight. Male C57BL/6J mice at 8 weeks of age were fed either a LFD (10% kcal as fat) or HFD (60% kcal as fat) with or without indicated dose of BL153 (2.5, 5, or 10 mg/kg body weight) for 24 weeks. (a) Body weight; (b) average energy intake for 12 weeks; (c) heart weight/tibia length ratio; and (d) insulin tolerance test (IPITT) as well as (e) area under the curves (AUC) after 20 weeks of control diet or HFD feeding. Data were presented as means ± SD (𝑛=5). ^a𝑃<0.05 versus control; ^b𝑃<0.05 versus HFD. Ctrl: control; HFD: high-fat diet.

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