New Insights into the Role of Mitochondrial Dynamics and Autophagy during Oxidative Stress and Aging in the Heart

<table>Mechanisms of mitophagy induction. Schema representing the main mechanisms of mitophagy induction. PINK1 accumulates in damaged mitochondria and phosphorylates mitofusin-2. Phosphorylated mitofusin-2 recruits parkin, which ubiquitinates several mitochondrial targets. Mitochondrial ubiquitination by parkin promotes mitophagy.</table>

Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: New Insights into the Role of Mitochondrial Dynamics and Autophagy during Oxidative Stress and Aging in the Heart 