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Oxidative Medicine and Cellular Longevity
Volume 2014, Article ID 273475, 8 pages
http://dx.doi.org/10.1155/2014/273475
Clinical Study

Increased Growth Factors Play a Role in Wound Healing Promoted by Noninvasive Oxygen-Ozone Therapy in Diabetic Patients with Foot Ulcers

Department of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China

Received 14 March 2014; Revised 25 April 2014; Accepted 27 May 2014; Published 24 June 2014

Academic Editor: Ersin Fadillioglu

Copyright © 2014 Jing Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [33 citations]

The following is the list of published articles that have cited the current article.

  • Vinnik, Plakhotnikova, Kirichenko, Kukonkov, and Teplyakova, “The application of directional flow of the ozoneoxygen gaseous mixture to a sanitation of pyogenic wounds in the experiment,” Novosti Khirurgii, vol. 23, no. 4, pp. 372–378, 2015. View at Publisher · View at Google Scholar
  • Jian Liu, Peng Zhang, Jing Tian, Lun Li, Jun Li, Jin Hui Tian, and KeHu YangCochrane Database of Systematic Reviews, 2015. View at Publisher · View at Google Scholar
  • Sofia Palagi, Isis Marques Severo, Doris Baratz Menegon, and Amalia de Fatima Lucena, “Laser therapy in pressure ulcers: evaluation by the Pressure Ulcer Scale for Healing and Nursing Outcomes Classification,” Revista da Escola de Enfermagem da USP, vol. 49, no. 5, 2015. View at Publisher · View at Google Scholar
  • Kamila Gebala-Prajsnar, Jaroslaw Pasek, Grzegorz Prajsnar, Andrzej Berszakiewicz, Aleksander Sieron, Agata Stanek, and Armand Cholewka, “Selected physical medicine interventions in the treatment of diabetic foot syndrome,” Acta Angiologica, vol. 21, no. 4, pp. 140–145, 2015. View at Publisher · View at Google Scholar
  • Giuseppe Valacchi, Claudia Sticozzi, Iacopo Zanardi, Giuseppe Belmonte, Franco Cervellati, Velio Bocci, and Valter Travagli, “ Ozone mediators effect on “ in vitro ” scratch wound closure ,” Free Radical Research, vol. 50, no. 9, pp. 1022–1031, 2016. View at Publisher · View at Google Scholar
  • A. Barone, M. Otero-Losada, Grangeat Am, G. Cao, F. Azzato, A. Rodríguez, and J. Milei, “Ozonetherapy protects from in-stent coronary neointimal proliferation. Role of redoxins,” International Journal of Cardiology, 2016. View at Publisher · View at Google Scholar
  • Hakan Turkon, Yıldıray Kalkan, Faruk Ozkul, M. Turgut Alper Ozkan, Mesut Erbas, Hasan Sahin, Tuncer Simsek, Ugur Altinisik, and Yavuz Demiraran, “The acute effects of preoperative ozone theraphy on surgical wound healing,” Acta Cirurgica Brasileira, vol. 31, no. 7, pp. 472–478, 2016. View at Publisher · View at Google Scholar
  • Fengmei Zhang, Yuguo Ren, Peng Liu, Yufeng Ren, and Debao Wang, “Expression of TGF-beta 1 and miRNA-145 in patients with diabetic foot ulcers,” Experimental And Therapeutic Medicine, vol. 11, no. 5, pp. 2011–2014, 2016. View at Publisher · View at Google Scholar
  • İsmail Demiryilmaz, Cebrail Gürsul, Merve Aydın, İlyas Sayar, Arda Işık, Şenol Biçer, and Kemal Peker, “Use of ozone to treat ileostomy dermatitis in an experimental rat model,” Medical Science Monitor, vol. 22, pp. 757–765, 2016. View at Publisher · View at Google Scholar
  • Aysan Lektemur Alpan, Hülya Toker, and Hatice Ozer, “Ozone Therapy Enhances Osseous Healing In Diabetic Rats With Calvarial Defect: A Morphometric and Immunohistochemical Study,” Journal of Periodontology, pp. 1–15, 2016. View at Publisher · View at Google Scholar
  • Zhiyuan Chen, Xiuheng Liu, Gang Yu, Hui Chen, Lei Wang, Zhishun Wang, Tao Qiu, and Xiaodong Weng, “Ozone therapy ameliorates tubulointerstitial inflammation by regulating TLR4 in adenine-induced CKD rats,” Renal Failure, pp. 1–9, 2016. View at Publisher · View at Google Scholar
  • Cüneyt Kahraman, Nail Kahraman, Ulviye Yalçinkaya, Aydin Akçilar, Gündüz Yümün, Engin Akgül, and Ahmet Hakan Vural, “Effects of hyperbaric oxygen therapy combined with platelet-rich plasma on diabetic wounds: An experimental rat model,” Archives of Medical Science, vol. 12, no. 6, pp. 1370–1376, 2016. View at Publisher · View at Google Scholar
  • Gang Yu, Xiuheng Liu, Hui Chen, Zhishun Wang, Zhiyuan Chen, Lei Wang, Tao Qiu, and Xiaodong Weng, “Ozone therapy could attenuate tubulointerstitial injury in adenine-induced CKD rats by mediating Nrf2 and NF-κB,” Iranian Journal of Basic Medical Sciences, vol. 19, no. 10, pp. 1136–1143, 2016. View at Publisher · View at Google Scholar
  • Ömer Coşkun, Mehmet Ali Şahin, Fatih Zor, Mehmet Tanyüksel, Yusuf Alper Sönmez, Yüksel Yurttaş, Mesut Mutluoğlu, Sabahattin Sari, Günalp Uzun, Demirhan Dal, Senol Yildiz, Adem Güler, and Şükrü Tekindur, “Approaches to Chronic Wound Care,” Gulhane Medical Journal, vol. 58, no. 2, pp. 207–228, 2016. View at Publisher · View at Google Scholar
  • Degli Agosti Irene, Elena Ginelli, Bruno Mazzacane, Gabriella Peroni, Sandra Bianco, Fabio Guerriero, Giovanni Ricevuti, Simone Perna, and Mariangela Rondanelli, “Effectiveness of a Short-Term Treatment of Oxygen-Ozone Therapy into Healing in a Posttraumatic Wound,” Case Reports in Medicine, vol. 2016, pp. 1–5, 2016. View at Publisher · View at Google Scholar
  • Gabriel Álvares Borges, Silvia Taveira Elias, Sandra Márcia Mazutti da Silva, Pérola Oliveira Magalhães, Sergio Bruzadelli Macedo, Ana Paula Dias Ribeiro, and Eliete Neves Silva Guerra, “In vitro evaluation of wound healing and antimicrobial potential of ozone therapy,” Journal of Cranio-Maxillofacial Surgery, vol. 45, no. 3, pp. 364–370, 2017. View at Publisher · View at Google Scholar
  • Gang Yu, Zhiming Bai, Zhiyuan Chen, Hui Chen, Guoren Wang, Gang Wang, and Zhenxiang Liu, “The NLRP3 inflammasome is a potential target of ozone therapy aiming to ease chronic renal inflammation in chronic kidney disease,” International Immunopharmacology, vol. 43, pp. 203–209, 2017. View at Publisher · View at Google Scholar
  • Weirong Xiao, Hua Tang, Meng Wu, Yangying Liao, Ke Li, Lan Li, and Xiaopeng Xu, “Ozone oil promotes wound healing by increasing the migration of fibroblasts via PI3K/Akt/mTOR signaling pathway.,” Bioscience reports, vol. 37, no. 6, 2017. View at Publisher · View at Google Scholar
  • Wen-Juan Tang, Long Jiang, Ying Wang, and Ze-Min Kuang, “Ozone therapy induced sinus arrest in a hypertensive patient with chronic kidney disease: A case report,” Medicine (United States), vol. 96, no. 50, 2017. View at Publisher · View at Google Scholar
  • Pao-Li Wang, Yoichi Tachi, Kazuya Masuno, Nobutaka Okusa, and Yasuhiro Imamura, “The Effect of Ozone Gel on Bone Matrix Production by Human Osteosarcoma Cell Line Saos-2,” Journal of Hard Tissue Biology, vol. 27, no. 3, pp. 195–198, 2018. View at Publisher · View at Google Scholar
  • Jelena Krunić, Nikola Stojanović, Ljiljana Đukić, Jelena Roganović, Branka Popović, Ivana Simić, and Dragica Stojić, “Clinical antibacterial effectiveness and biocompatibility of gaseous ozone after incomplete caries removal,” Clinical Oral Investigations, 2018. View at Publisher · View at Google Scholar
  • Mukul Ashtikar, and Matthias G. Wacker, “Nanopharmaceuticals for wound healing –Lost in translation?,” Advanced Drug Delivery Reviews, 2018. View at Publisher · View at Google Scholar
  • Erin Fitzpatrick, Olivia J Holland, and Jessica J Vanderlelie, “Ozone therapy for the treatment of chronic wounds: A systematic review,” International Wound Journal, 2018. View at Publisher · View at Google Scholar
  • Qinghai Zeng, Jian Huang, Jinhua Huang, Mingsheng Song, Yaping Xiang, Lihua Gao, Kathy Wu, and Jianyun Lu, “The antibacterial effect of topical ozone on the treatment of MRSA skin infection,” Molecular Medicine Reports, vol. 17, no. 2, pp. 2449–2455, 2018. View at Publisher · View at Google Scholar
  • Zeynep Tastan Eroglu, Bulent Kurtis, Hasan Ayberk Altug, Sermet Sahin, Gulay Tuter, and Emre Baris, “Effect of topical ozonetherapy on gingival wound healing in pigs: histological and immuno-histochemical analysis,” Journal of Applied Oral Science, vol. 27, no. 0, 2018. View at Publisher · View at Google Scholar
  • Morteza Izadi, Ramin Kheirjou, Roya Mohammadpour, Mohammad Hassan Aliyoldashi, Saeedreza Jamali Moghadam, Farzin Khorvash, Nematollah Jonaidi Jafari, Shahram Shirvani, and Nahid khalili, “Efficacy of comprehensive ozone therapy in diabetic foot ulcer healing,” Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2018. View at Publisher · View at Google Scholar
  • Mehmet Erdogan, Mustafa Kulaksizoglu, Asli Tetik, Soner Solmaz, Ali Sahin Kucukaslan, and Zuhal Eroglu, “The relationship of the endothelial nitric oxide synthase (eNOS) and vascular endothelial growth factor (VEGF) gene polymorphism in Turkish type 2 diabetic patients with and without diabetic foot ulcers,” The Foot, vol. 37, pp. 5–10, 2018. View at Publisher · View at Google Scholar
  • Ning Xu, Lili Wang, Ning He, Wei Zhang, Junjie Guan, Chao Tang, and Shiping Fu, “Wound healing effects of a Curcuma zedoaria polysaccharide with platelet-rich plasma exosomes assembled on chitosan/silk hydrogel sponge in a diabetic rat model,” International Journal of Biological Macromolecules, vol. 117, pp. 102–107, 2018. View at Publisher · View at Google Scholar
  • Robert Kushmakov, Jason Gandhi, Omar Seyam, Wendy Jiang, Gunjan Joshi, NoelL Smith, and SardarAli Khan, “Ozone therapy for diabetic foot,” Medical Gas Research, vol. 8, no. 3, pp. 111, 2018. View at Publisher · View at Google Scholar
  • Resitoglu, Celik, Komur, Polat, Erdogan, Arslankoylu, and Beydagi, “The efficacy of ozone therapy in neonatal rats with hypoxic ischemic brain injury,” Bratislava Medical Journal, vol. 119, no. 2, pp. 81–85, 2018. View at Publisher · View at Google Scholar
  • Aytuğ Koçyiğit, Duygu Kumbul Doğuç, Şenol Gülmen, Tunay Kurtoğlu, Ibrahim Meteoğlu, Hüseyin Okutan, and Filiz Alkaya Solmaz, “The effect of ozone treatment on remote organ myocardial injury in an aortic ischemia-reperfusion model,” Turkish Journal of Thoracic and Cardiovascular Surgery, vol. 26, no. 2, pp. 207–213, 2018. View at Publisher · View at Google Scholar
  • Ciro D. Soares, Thayná M. L. Morais, Roberta M. F. G. Araújo, Patrícia F. Meyer, Eric A. F. Oliveira, Rodrigo M. V. Silva, Eneida M. Carreiro, Edvaldo P. Carreiro, Verônica G. Belloco, Bruno A. L. A. Mariz, and Jacks Jorge-Junior, “Effects of subcutaneous injection of ozone during wound healing in rats,” Growth Factors, pp. 1–9, 2019. View at Publisher · View at Google Scholar
  • Rosaria Di Mauro, Giuseppina Cantarella, Renato Bernardini, Michelino Di Rosa, Ignazio Barbagallo, Alfio Distefano, Lucia Longhitano, Nunzio Vicario, Daniela Nicolosi, Giacomo Lazzarino, Daniele Tibullo, Maria Gulino, Mariarita Spampinato, Roberto Avola, and Giovanni Li Volti, “The Biochemical and Pharmacological Properties of Ozone: The Smell of Protection in Acute and Chronic Diseases,” International Journal of Molecular Sciences, vol. 20, no. 3, pp. 634, 2019. View at Publisher · View at Google Scholar