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Oxidative Medicine and Cellular Longevity
Volume 2014, Article ID 273692, 10 pages
http://dx.doi.org/10.1155/2014/273692
Research Article

Vitamin A Supplementation Alleviates Extrahepatic Cholestasis Liver Injury through Nrf2 Activation

Department of Biliary-Pancreatic Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China

Received 19 January 2014; Revised 12 June 2014; Accepted 17 June 2014; Published 9 July 2014

Academic Editor: Felipe Dal-Pizzol

Copyright © 2014 Guiyang Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. G. Roma and E. J. Sanchez Pozzi, “Oxidative stress: a radical way to stop making bile,” Annals of Hepatology, vol. 7, no. 1, pp. 16–33, 2008. View at Google Scholar · View at Scopus
  2. B. L. Copple, H. Jaeschke, and C. D. Klaassen, “Oxidative stress and the pathogenesis of cholestasis,” Seminars in Liver Disease, vol. 30, no. 2, pp. 195–204, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Anthérieu, P. B. Azzi, J. Dumont et al., “Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells,” Hepatology, vol. 57, no. 4, pp. 1518–1529, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. K. Jung and M. Kwak, “The Nrf2 system as a potential target for the development of indirect antioxidants,” Molecules, vol. 15, no. 10, pp. 7266–7291, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. V. Barón and P. Muriel, “Role of glutathione, lipid peroxidation and antioxidants on acute bile-duct obstruction in the rat,” Biochimica et Biophysica Acta, vol. 1472, no. 1-2, pp. 173–180, 1999. View at Publisher · View at Google Scholar · View at Scopus
  6. A. R. Soylu, H. Umit, A. Tezel et al., “Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats,” World Journal of Gastroenterology, vol. 12, no. 42, pp. 6835–6841, 2006. View at Google Scholar · View at Scopus
  7. Y. L. Tain, C. C. Chen, C. T. Lee et al., “Melatonin regulates L-Arginine transport and NADPH oxidase in young rats with bile duct ligation: role of protein kinase C,” Pediatric Research, vol. 73, no. 4, part 1, pp. 395–401, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Tokac, G. Taner, S. Aydin et al., “Protective effects of curcumin against oxidative stress parameters and DNA damage in the livers and kidneys of rats with biliary obstruction,” Food and Chemical Toxicology, vol. 61, pp. 28–35, 2013. View at Publisher · View at Google Scholar
  9. M. Galicia-Moreno, L. Favari, and P. Muriel, “Antifibrotic and antioxidant effects of N-acetylcysteine in an experimental cholestatic model,” European Journal of Gastroenterology and Hepatology, vol. 24, no. 2, pp. 179–185, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. T. Nguyen, P. Nioi, and C. B. Pickett, “The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress,” Journal of Biological Chemistry, vol. 284, no. 20, pp. 13291–13295, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. S. K. Niture, J. W. Kaspar, J. Shen, and A. K. Jaiswal, “Nrf2 signaling and cell survival,” Toxicology and Applied Pharmacology, vol. 244, no. 1, pp. 37–42, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. D. D. Zhang, “Mechanistic studies of the Nrf2-Keap1 signaling pathway,” Drug Metabolism Reviews, vol. 38, no. 4, pp. 769–789, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. C. Chen, D. Pung, V. Leong et al., “Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals,” Free Radical Biology and Medicine, vol. 37, no. 10, pp. 1578–1590, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. W. Jeong, M. Jun, and A. T. Kong, “Nrf2: a potential molecular target for cancer chemoprevention by natural compounds,” Antioxidants and Redox Signaling, vol. 8, no. 1-2, pp. 99–106, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. B. N. Das, Y. Kim, and Y. Keum, “Mechanisms of Nrf2/keap1-dependent phase II cytoprotective and detoxifying gene expression and potential cellular targets of chemopreventive isothiocyanates,” Oxidative Medicine and Cellular Longevity, vol. 2013, Article ID 839409, 7 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. J. W. Kaspar, S. K. Niture, and A. K. Jaiswal, “Nrf2:INrf2 (Keap1) signaling in oxidative stress,” Free Radical Biology and Medicine, vol. 47, no. 9, pp. 1304–1309, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. W. S. Blaner, S. M. O'Byrne, N. Wongsiriroj et al., “Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage,” Biochimica et Biophysica Acta, vol. 1791, no. 6, pp. 467–473, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Venu, E. Martin, K. Saeian, and S. Gawrieh, “High prevalence of vitamin A deficiency and vitamin D deficiency in patients evaluated for liver transplantation,” Liver Transplantation, vol. 19, no. 6, pp. 627–633, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. H. He, A. Mennone, J. L. Boyer, and S. Cai, “Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct-ligated rats and human hepatic cells,” Hepatology, vol. 53, no. 2, pp. 548–557, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. H. Wang, Z. Dan, and H. Jiang, “Effect of all-trans retinoic acid on liver fibrosis induced by common bile duct ligation in rats,” Journal of Huazhong University of Science and Technology-Medical Science, vol. 28, no. 5, pp. 553–557, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. K. Murakami, T. Kaji, R. Shimono et al., “Therapeutic effects of vitamin A on experimental cholestatic rats with hepatic fibrosis,” Pediatric Surgery International, vol. 27, no. 8, pp. 863–870, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Floreani, A. Baragiotta, D. Martines, R. Naccarato, and A. D'Odorico, “Plasma antioxidant levels in chronic cholestatic liver diseases,” Alimentary Pharmacology and Therapeutics, vol. 14, no. 3, pp. 353–358, 2000. View at Publisher · View at Google Scholar · View at Scopus
  23. F. Zhao, T. Wu, A. Lau et al., “Nrf2 promotes neuronal cell differentiation,” Free Radical Biology and Medicine, vol. 47, no. 6, pp. 867–879, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. O. Carvalho and C. Gonçalves, “Retinol and retinyl palmitate in foetal lung mice: sexual dimorphism,” Critical Care Research and Practice, vol. 2013, Article ID 760305, 7 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Rasmussen, R. Blomhoff, P. Helgerud, L. A. Solberg, T. Berg, and K. R. Norum, “Retinol and retinyl esters in parenchymal and nonparenchymal rat liver cell fractions after long-term administration of ethanol,” Journal of Lipid Research, vol. 26, no. 9, pp. 1112–1119, 1985. View at Google Scholar · View at Scopus
  26. M. W. Schäffer, S. S. Roy, S. Mukherjee et al., “Qualitative and quantitative analysis of retinol, retinyl esters, tocopherols and selected carotenoids out of various internal organs from different species by HPLC,” Analytical Methods, vol. 2, no. 9, pp. 1320–1332, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. V. Witko-Sarsat, M. Friedlander, C. Capeillère-Blandin et al., “Advanced oxidation protein products as a novel marker of oxidative stress in uremia,” Kidney International, vol. 49, no. 5, pp. 1304–1313, 1996. View at Publisher · View at Google Scholar · View at Scopus
  28. Y. S. Keum, “Regulation of Nrf2-mediated phase II detoxification and anti-oxidant genes,” Biomolecules & Therapeutics, vol. 20, no. 2, pp. 144–151, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. K. Okada, J. Shoda, K. Taguchi et al., “Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems,” Biochemical and Biophysical Research Communications, vol. 389, no. 3, pp. 431–436, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. A. T. Dinkova-Kostova and P. Talalay, “NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector,” Archives of Biochemistry and Biophysics, vol. 501, no. 1, pp. 116–123, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. D. Martin, A. I. Rojo, M. Salinas et al., “Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/ Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol,” The Journal of Biological Chemistry, vol. 279, no. 10, pp. 8919–8929, 2004. View at Publisher · View at Google Scholar · View at Scopus